Big 12 Championship Picks: Bet Houston Over Iowa State
The Big 12 championship offers a Top-10 showdown as No. 1 Houston takes on No. 7 Iowa State in downtown Kansas City. Houston is a 5 1/2-point favorite against Iowa State in the NCAAB point spreads. The over-under is set at 121½ points.
Let’s take a look at our NCAA basketball picks for the Big 12 title game.

Good Night from Kansas City.
Cyclones. Coogs.
For a Championship. 🏆⏳ pic.twitter.com/X3ta64T53l
— Big 12 Conference (@Big12Conference) March 16, 2024
Iowa State vs Houston Game Information
- Game: Iowa State (26-7, 13-5 Big 12) vs Houston (30-3, 15-3)
- Date/Time: Saturday, March 16, 6 p.m. ET
- Location: T-Mobile Center, Kansas City, MO
- Iowa State vs Houston Live Stream: TBS.com
The Iowa State Cyclones are a 5 1/2-point underdog against the Houston Cougars in the NCAAB odds. This Big 12 championship matchup tips off on Saturday, March 16, at 6 p.m. from Kansas City. Fans can watch this Top-10 showdown on ESPN or stream via ESPN+.
Iowa State vs Houston Odds and Spreads
Iowa State vs Houston Betting Trends
- Houston is 16-15-2 against the spread (ATS) in the NCAA basketball odds.
- Iowa State has made bettors money going 21-10-2 ATS this season.
- The Cougars have gone 30-3 as a betting favorite in 2023-24.
- Iowa State is 4-0-1 ATS in its last five games as an underdog.
- Houston has gone under in 19 games, and the over has hit 14 times.
- Cyclones games have gone under in six of the last seven matchups.
- The over is 4-1 in the Cougars’ last five games as a favorite of 6.5 points or less.
- Iowa State has gone under in 17 games, while the over has hit 16 times.
Iowa State vs Houston Over/Under Pick: Over 121½ (-110)
These are two of the nation’s top five defenses squaring off, so we have to hammer the under, right? Well, the college basketball odds also have factored in stingy defenses.
12 games later… it is settled. pic.twitter.com/BmGdn16JO6
— Big 12 Conference (@Big12Conference) March 16, 2024
The last time these teams squared off on February 19, they combined for 138 points. Houston has also scored 75 or more points in three of their last five matchups.
We’re taking the over in the Big 12 title game.
Iowa State vs Houston ATS Pick: Houston -5 ½ (-110)
Iowa State has essentially turned every contest at the T-Mobile Center in downtown Kansas City into a home game. The Cyclones were undefeated at home this season, and the Big 12 tournament has become a de facto home game thanks to Iowa State fans traveling.
Iowa State is back on the 2 seed line. Pure decimation of Baylor tonight in Kansas City.
Houston awaits on Saturday for the title.
A word to the wise: Don’t show up if you’re soft.
— Jon Rothstein (@JonRothstein) March 16, 2024
That said, Houston is playing at another level heading into March Madness. These teams split their two regular-season matchups. Bet online Houston to cover the 5 1/2-point spread.
Iowa State vs Houston Best Prop Bet: Race to 10 Points- Houston (-148)
Houston has a strong track record of getting out to a fast start, while its opponents struggle to score. Take Houston to win the race to 10 points at the sportsbook.
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Iowa State vs Houston Prediction
Questions of the Day
What are Houston's odds to win the national championship?
Houston is second in the NCAA tournament championship odds at +550.
What are Houston’s odds to make the Final Four?
Houston has +115 odds to make the Final Four.