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Houston vs Duke Betting Trends for CBB Sweet 16

Top-seeded Houston had to fight hard to get to the Sweet 16, but the NCAAB lines have it as the favorite against fourth-seeded Duke, which has cruised to this point of the Big Dance. Both of these teams are used to playing at this time of the season, with the Cougars making their fourth straight appearance in the Sweet 16, while the Blue Devils advanced to the Final Four in 2022.


Houston vs Duke Betting Trends for CBB Sweet 16
Houston vs Duke Betting Trends for CBB Sweet 16

Houston had to fight off a furious rally by Texas A&M in the second round, advancing in overtime, while Duke routed James Madison to get to this point in the tournament. The Las Vegas college basketball odds are favoring Houston heading into this one, but let’s take a closer look before you make your wagers.

Houston vs Duke Game Information

  • Game: Houston (32-4) vs Duke (26-8)
  • Date/Time: Friday, March 29, 9:39 p.m. ET
  • Location: American Airlines Center, Dallas, Texas
  • Houston vs Duke Live Stream:TBS.com


This will be the first meeting on the hardwood in the long histories of Duke and Houston basketball. The NCAA basketball odds give the edge to the Cougars in this one, favoring them by four points, while the over/under for this contest has been set at 134½ points.


Houston vs Duke Odds and Spreads

  • Duke is 6-0 ATS in its last six neutral-site games as an underdog.
  • Houston is 17-17-2 ATS this season.
  • The under is 4-0 in the Blue Devils’ last four NCAA Tournament games.
  • The over is 4-0 in the Cougars’ last four NCAA Tournament games as a favorite.
  • Duke is 1-7 ATS in its last eight games as an underdog of up to 6½ points.
  • The under is 20-16-0 in Houston’s 36 games this season.
  • Duke is 0-2 as an underdog in 2023-24.
  • The Blue Devils are 20-14-0 ATS this season.


Over/Under Pick: Under 134½

This game between two of the favorites of March Madness betting is going to be a physical battle from the opening tip. Both teams are very solid defensively, so scoring is going to be a premium. Houston is giving up the fewest points per game in the country at 57.7. Duke is no slouch either, ranking 31st in allowing 66.5 points per contest.

The Cougars are going to be on high alert on the defensive end after giving up 95 points to Texas A&M in the second round. Duke must be very careful with the basketball as Houston is 12th in the country, forcing 15.86 turnovers per game. They can turn into easy buckets that will rev up the Cougars, which is why the NCAAB lines have the under so low in this one.



ATS Pick: Houston -4

Kelvin Sampson’s team has been driving hard for a national title for the last few seasons, reaching the Final Four in 2021 and the Elite Eight in 2022. This team has experience and depth, wearing down opponents with constant physical pressure. Guard L.J. Cryer, the team’s leading scorer at 15.5 points per game, was a freshman on Baylor’s 2021 national championship squad, so he brings that experience and a drive for a second title.

If Duke is going to stay in this one, it has to have a big game from leading scorer and rebounder Kyle Filipowski (16.6 points, 8.2 rebounds per game). The sophomore 7-footer has to handle the physical play of the Cougars on the interior as well as do some scoring from the perimeter. If he can be at his best, the Blue Devils will have a chance to go against the NCAAB expert picks and knock off the Cougars.



Player Prop Pick: Jamal Shead Over 6½ Assists (-107)

Houston’s offense is run by senior guard Jamal Shead, who scores 13.8 points but is also 17th in the country in assists per contest with 6.4. Shead has turned it up over the last couple of weeks, dishing out nine or more assists in three of the Cougars’ last four games.

Expect that trend to continue in this contest as Shead looks to get his teammates good looks at the basket. Houston’s offense can be high octane when Shead is at his best, so make sure your betting online includes this prop wager.

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Houston 70, Duke 61



Questions of the Day

Have Houston and Duke faced each other before?

These two teams have never met on the hardwood, so this will be the first meeting between these storied programs.

Who does the winner of the Houston vs Duke game face next?

The winner of this contest advances to the South Region final on Sunday where it will face either NC State or Marquette.

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