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Purdue vs Gonzaga College Basketball Tourney Picks for Sweet 16

After struggling against double-digit seeds in recent seasons, Purdue has looked like it’s going to live up to its place among the best March Madness betting odds as the top seed in the Midwest Region – though it has quite a test on Friday in fifth-seeded Gonzaga. The Boilermakers have steamrolled a pair of opponents in this season’s Big Dance and are looking for their first Elite Eight appearance since 2019 with a win over the Bulldogs in Detroit.

Gonzaga has also been impressive in this year’s tournament, especially in a 21-point rout of Kansas on Saturday, and it is making its ninth straight appearance in the Sweet 16. The college basketball lines are favoring the Boilermakers in this one, but the Bulldogs are not going to go down without a fight.

Purdue vs Gonzaga College Basketball Tourney Picks for Sweet 16
Purdue vs Gonzaga College Basketball Tourney Picks for Sweet 16

Game Information

  • Game: Purdue (31-4) vs Gonzaga (27-7)
  • Date/Time: Friday, March 29, 7:39 p.m. ET
  • Location: Little Caesars Arena, Detroit, Mich.
  • Purdue vs Gonzaga Live Stream: TBS.com


Purdue is undefeated in four meetings with Gonzaga, which includes a matchup in this season’s Maui Invitational in Hawaii in November. The Boilermakers earned a 10-point win (73-63) in that game. The NCAAB odds favor the Boilermakers to repeat that feat in Friday’s contest, with Purdue giving 5½ points on a point-spread bet. The over/under has been set at 154½ points.


Purdue vs Gonzaga Odds and Spreads


  • Gonzaga is 5-1 ATS in its last six games.
  • Purdue is 29-4 as the favorite this season.
  • The over is 8-0 in the Boilermakers’ last eight NCAA Tournament games as a favorite of up to 6½ points.
  • The Bulldogs are 1-8-1 ATS in their last 10 Friday games.
  • The over is 4-0 in Purdue’s last four games following an ATS win.
  • The Bulldogs are 0-4 ATS in their last four NCAAB Tournament games as an underdog.
  • The over is 23-12-0 in Purdue’s 35 games this season.
  • Gonzaga is 2-2 as an underdog in 2023-24.


Over/Under Pick: Under 154½

With one of the most intimidating big men in the country patrolling the paint in 7-4 Zach Edey, Purdue has been one of the better defensive teams in the country this season, allowing 69.5 points per game. In the Maui matchup, the Boilermakers limited Gonzaga to 63 points on 37.7% shooting from the field, and we could see more of that in this game.

The Bulldogs’ best chance in this one is to make the game a track meet much like they did in the second half against Kansas. After trailing by one at halftime, Gonzaga outscored the Jayhawks 46-24 in the second half to win going away. That’s not going to be as easy to do against Purdue, however, so your bets on March Madness should include the under in this one.


ATS Pick: Purdue -5½

After becoming just the second No. 1 seed to lose to a 16 seed last season, Purdue is looking to become the second team to follow that up with a national title the following year – like Virginia did in 2019. Having the reigning National Player of the Year in Edey on the floor is a major help, as he dominates against any opponent the Boilermakers face.

But this season’s team is much more than Edey, with sophomore guard Braden Smith (12.3 points, 5.7 rebounds, 7.3 assists) leading a more confident supporting cast that can burn a defense that focuses too much on the big man. Gonzaga is better than it was earlier this season, with junior forward Graham Ike (16.4 points, 7.3 rebounds) the team’s main offensive threat, but Purdue is just too good and should live up to the college basketball predictions with a win.


Team Prop Pick: First Half Under 73 (-110)

This game is going to be a hard-fought battle, and we think both teams will be a little tight in the first half of Friday’s contest. With nearly a week off, both teams will have a lot of adrenaline, which will cause offense to be a little harder as shooters won’t be settled into the contest just yet.

Gonzaga held a 35-30 lead at halftime of the first meeting between these teams this season, and we expect that kind of defensive result in the first 20 minutes of this game. Take the first-half under in a very important contest for both teams.


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Score Prediction

Purdue 79, Gonzaga 70



Questions Of The Day

Who won the last matchup between Purdue and Gonzaga?

These two teams played each other earlier this season in the Maui Invitational in November, with Purdue coming out on top, 73-63

Who does the winner of the Purdue vs Gonzaga game face next?

The winner of this contest advances to Sunday’s Midwest Region final, where it will face either Creighton or Tennessee for a trip to the Final Four.

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