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Arizona vs Duke Odds, Sweet Sixteen Prediction and March Madness Picks March 27
- Look for the Arizona vs Duke game to go over 154 points.
- Take Duke’s Cooper Flagg to go over 21.5 points.
- Make bank with our top NCAAB picks! Join with our promo code HUDDLE125.
Arizona vs Duke March Madness Odds
While Duke and Arizona met in each of the last two seasons, Thursday’s Sweet 16 game will be the first March Madness matchup between the teams since 2011.
Duke has won its first two tournament games by 44 and 23 points while Arizona had a battle past former conference rival Oregon to make it to the regionals for the third time in the last four seasons.
The March Madness betting lines list Duke as the 9.5-point favorite with -550 odds to win outright. Arizona has +425 odds to advance to the Elite Eight.
Duke is at +225 in the March Madness odds. Arizona comes in at +4000 in the NCAAM championship odds. The Blue Devils are at -200 to win the East Region title in the NCAA basketball odds.
Arizona vs Duke Prediction Today March 27
My Prediction
Duke 85, Arizona 74
Arizona guard Caleb Love saw plenty of the Duke Blue Devils during his four seasons at North Carolina. He is hoping that his college career doesn’t come to an end against the rival Duke Blue Devils.
“We’ll be ready for them.”
Caleb Love on facing Duke in the Sweet 16. pic.twitter.com/XDzH174lpX
— CBS Sports (@CBSSports) March 24, 2025
Love had just eight points on 3-of-13 shooting in a 69-55 loss to Duke when listed by the BetUS sportsbook as a 1.5-point home favorite on Nov. 22.
Arizona hasn’t faced a No. 1 seed in the March Madness bracket since 2015, so don’t read too much into the fact that the Wildcats are 8-3 against the odds in their last 11 meetings with a top-seeded team, per NCAA betting trends.
Duke’s last meeting with a No. 4 seed resulted in a loss to Tennessee in 2023.
Keep that in mind when making NCAA basketball picks.
Top 3 Arizona vs Duke Betting Picks
My top picks
1. Arizona vs Duke ATS Pick: Duke +9 points
2. Arizona vs Duke O/U Pick: Over 154 points
3. Arizona vs Duke best player prop bet: Arizona’s Jaden Bradley 20+ combined points, rebounds and assists (-110)
My Analysis
Duke is going to be tested one of these days in the NCAA Tournament, right?
Arizona began March by losing two of its first three games. The Wildcats seemed to hit their stride in the Big 12 tournament before falling in the final to Houston. They will need to play better defensively than they did the last time out, with Oregon’s struggles from the foul line helping Arizona to advance.
Arizona is averaging 90 points in the first two March Madness games with Duke putting up 91 points, so when making March Madness picks, take the game to land over when making March Madness predictions.
Arizona vs Duke March Madness Best Point- Scorer Prop
Cooper Flagg Over 21.5 Points (-114)
Freshman sensation Cooper Flagg hasn’t been asked to light things up for Duke so far in the NCAA Tournament as he has 32 points in 51 minutes. It could be a different deal against Arizona as he will be a preferred option in the March Madness expert picks.
“We’ll be ready for them.”
Caleb Love on facing Duke in the Sweet 16. pic.twitter.com/XDzH174lpX
— CBS Sports (@CBSSports) March 24, 2025
Flagg went off for 24 points in the regular-season matchup with Arizona. Take the -114 odds for Flagg to go over 21.5 points when considering college basketball prop bets.
Arizona vs Duke How to Watch
- Game: Arizona (24-12) vs Duke (33-3)
- Date/Time: Thursday, March 27, 9:39 p.m. ET
- Location: Prudential Center, Newark, NJ
- Arizona vs Duke Live Stream: Fubo.tv
Check here for Arizona vs Duke stats.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
