Arkansas vs St. John’s Odds, Second Round Prediction and March Madness Picks, March 22

For the second time in as many 2025 March Madness matchups involving the Arkansas Razorbacks, the head coaches will be in the spotlight. John Calipari, who just led the Razorbacks past Kansas and former championship-winning coach Bill Self, now matches wits against Rick Pitino and the second-seeded St. John’s Red Storm.

Pitino and Calipari led their teams against each other 15 times as college head coaches, with Calipari’s teams winning nine times. Calipari’s squads are 2-1 in the NCAA Tournament when meeting up with a team coached by Pitino. It is safe to say the two are not close friends.

St. John’s is listed by the college basketball lines as the 7-point favorite with -290 odds to win outright. Arkansas has +240 odds to advance to the Sweet 16 for the third time in the last four seasons.

ARKANSAS ELIMINATES KANSAS FOR THE SECOND TIME IN THE LAST THREE YEARS 😳

John Calipari wins his first NCAA tournament game with Arkansas 👏 pic.twitter.com/bJcZ1p4imJ

— SportsCenter (@SportsCenter) March 21, 2025

St. John’s is at +2000 in the March Madness odds. Arkansas is well back at +20000 in the championship odds. The odds for the NCAAB championship have St. John’s (+450) among the leading contenders in the West Region title odds.

Arkansas vs St. John’s Prediction Today March 22

My Prediction

St. John’s 72, Arkansas 66

It has taken Pitino just two seasons to get St. John’s to the top of the Big East and in contention for a national championship. Calipari ended his successful run at Kentucky and stayed in the SEC to coach at Arkansas.

Arkansas knocked off Kansas to set up this made-for-TV matchup. It might be asking a bit much for the Razorbacks to play their way into the regionals when making college basketball picks.

However, the Razorbacks could make enough shots to improve to 9-7 against the spread as the underdog this season. Keep that in mind when it is time to bet on March Madness.

Top 3 Arkansas vs St. John’s Betting Picks

My top picks

1. Arkansas vs St. John’s ATS Pick: Arkansas +7 points
2. Arkansas vs St. John’s O/U Pick: Over 144 points
3. Arkansas vs St. John’s best point-scorer bet: Arkansas guard Johnell Davis 15+ points (-104)

My Analysis

St. John’s went 5-1 against ranked teams this season. The loss came against Georgia, a conference rival of Arkansas. The Razorbacks were just 4-7 when facing ranked teams, per NCAA betting trends.

NEXT 🆙

(Don’t worry #JohnnieNation you won’t have to take a nap before this one) pic.twitter.com/ejRLPjXSL1

— St. John’s Men’s Basketball (@StJohnsBBall) March 21, 2025

Both teams headed into the March Madness tournament in the top 20 in the Pomeroy basketball database. The question is whether Arkansas can score frequently enough against the top-rated defensive team in the country.

Taking the game to land over the 144-point total set by the BetUS sportsbook could be a little risky with the way St. John’s shuts down opposing offenses. When considering some expert NCAAB picks, Arkansas had some turnover issues early in the second half in the win over Kansas and that could be a recipe for disaster if that happens against the Red Storm.

Arkansas vs St. John’s March Madness Best Prop Bet

Kadary Richmond 30+ Points, Rebounds and Assists (+106)

Kadary Richmond flirted with a triple-double in the March Madness opener before finishing with 10 points, eight rebounds and six assists in the win over Omaha. It might be a little more challenging against an athletic Arkansas backcourt.

When considering college basketball prop bets, take the +106 odds for Richmond to have 30+ combined points, rebounds and assists as he looks to make some March Madness news.

Arkansas vs St. John’s How to Watch

• Game: Arkansas Razorbacks (21-13) vs St. John’s Red Storm (31-4)
• Date/Time: Saturday, March 22, 2:40 p.m. ET
• Location: Amica Mutual Pavilion, Providence, RI
• Arkansas vs St. John’s Live Stream: Fubo.tv

Check here for Arkansas vs St. John’s stats.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.