Creighton vs Auburn Odds, Second-Round Prediction and March Madness Picks March 22

The Auburn Tigers look to find their top form as a favorite in the college basketball betting odds when they face the dangerous Creighton Bluejays in the second round of the NCAA Tournament at Lexington, Ky., on Saturday night.

Creighton shot 57.1 percent from the field on the way to a decisive 89-75 victory over Louisville in the first round. The Bluejays need a similar effort to reach the Sweet 16 for the fourth time in five years.

Auburn is +450 in the odds to win the NCAA basketball championship, but the Tigers didn’t look like a contender in the first half on Thursday. Auburn rebounded in the final 20 minutes to beat Alabama State 83-63.

Creighton vs Auburn Prediction Today March 22

My prediction

Auburn 78, Creighton 74

The Tigers are too good to let this chance for a big run to the Final Four get away, so we expect them to find the answers Saturday. Creighton has the tools to stay right with Auburn throughout and is worthy of your March Madness bet to beat the spread. The Jays are 20-13-2 ATS.

Auburn HC Bruce Pearl: “We’re not playing as well as we were a month ago. It’s not a good time to be in that situation. But can we get it turned around and beat a really good Creighton team? Yeah, we can.”

— Justin Ferguson (@JFergusonAU) March 20, 2025

Creighton vs Auburn Betting Picks

My top picks

1. Creighton vs Auburn ATS Pick: Creighton +9 points
2. Creighton vs Auburn O/U Pick: Bet over 150 ½ points
3. Creighton vs AuburnBest Ponit-score Bet: Denver Jones Over 10.5 points

My analysis

Creighton played one of its best games of the season on Thursday and should come in loose and ready to give Auburn a big scare.

The Bluejays will need big performances from their top three players center Ryan Kalkbrenner, 3-point ace Steven Ashworth and emerging star Jamiya Neal, who scored a career-high 29 points against Louisville.

Jamiya Neal was a PROBLEM today 😤

29 PTS | 11-16 FG | 12 REB #MarchMadness pic.twitter.com/c372pjml3V

— NCAA March Madness (@MarchMadnessMBB) March 20, 2025

This should be one of the best college basketball games Saturday with Auburn’s deep, talented lineup wearing Creighton down. Player of the year candidate Johni Broome leads the Tigers, but the keys may be his supporting players.

A shootout is our expert NCAA basketball pick because the two teams have combined for 646 made 3-pointers. Miles Kelly boasts 16 made 3-pointers in two games at Rupp Arena this season for Auburn and Creighton drained 11-of-24 on Thursday.

Denver Jones on Miles Kelly’s 7 threes against Alabama State, totaling 16 combined in two games at Rupp Arena this season:

“He’s one of the best shooters in America.” pic.twitter.com/nPoYSjGT8a

— Auburn Tigers | AL.com (@aldotcomTigers) March 20, 2025

The Tigers’ guards have taken turns producing big games and Denver Jones could be the player to step up in this contest. He had eight points and six assists versus Alabama State. Check late NCAA basketball news for any injury updates.

Creighton vs Auburn March Madness Best Prop Pick

Bet First Shot Made (+125)

These two teams shoot the ball very well and you are getting pretty good odds for the first attempt to go in on Saturday night.

Both have big men who can get an easy one inside. Jamiya Neal gives Creighton a one-on-one threat and both teams can make 3-pointers to cash this prop bet. We think that gives us a good betting value and you can also use it in an NCAAB parlay pick.

Creighton vs Auburn How to Watch

• Game: Creighton Blue Jays (25-10) vs Auburn Tigers (29-5)
• Date/Time: Saturday, March 22, 7:10 p.m. ET
• Location: Rupp Arena, Lexington, Ky
• Blue Jays vs Tigers Live Stream: fubo.tv

Get updated Creighton vs Auburn stats here.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.