Creighton vs Louisville Odds, Prediction and March Madness Picks March 20

This is a first-round NCAA basketball game I would love to see in person. Creighton is fresh off a run to the Big East tournament title game while Louisville squandered an opportunity to beat a Cooper Flagg-less Duke team in the ACC tournament final. Now they are 40 minutes away from a potential matchup with top-seeded Auburn.

When Creighton beat Louisville in the first round of the 1999 NCAA tournament, who would have imagined that it would be 26 years before they would meet again?

Both these teams are six games over .500 against the NCAA basketball odds this season.

Louisville is listed by the college basketball lines as the 2.5-point favorite with -145 odds to win outright. The +125 Moneyline for Creighton to win is sure to generate plenty of action.

Louisville is tied for 21st at +8000 in our odds for March Madness. Creighton (+10000) comes in tied at 25th in the championship odds. The college basketball futures odds have Louisville (+2200) tied for sixth in the South Region title odds.

Creighton vs Louisville Prediction Today (3-20)

My Prediction

Creighton 73, Louisville 71

Louisville has been quite the story. Five teams had shorter odds of winning the ACC title when the season began, only to finish second in the conference during the regular season and in the tournament.

Their reward is a matchup with a veteran Creighton team just to set up a possible second-round game with Auburn.

Creighton coach Greg McDermott, asked what he’s learned about Louisville: “I can’t believe they’re an 8 seed.” pic.twitter.com/HlsWfrodWV

— Jon Walker (@ByJonWalker) March 18, 2025

When making March Madness bets, remember that the teams are a combined 5-10 against ranked teams this season. Creighton is 7-2-1 ATS as the underdog this season. That is enough to go with Creighton to cover in this huge first-round matchup.

Top 3 Creighton vs Louisville Betting Picks

1. Creighton +2.5 (-105)
2. Creighton vs Louisville Under 145.5
3. Creighton vs Louisville best point-scorer bet: Terrence Edwards 20+ Points (+104)

My Analysis

Creighton’s fifth-year seniors Ryan Kalkbrenner and Steven Ashworth helped the Bluejays reach the Sweet 16 in the 2024 March Madness bracket. Those making NCAAB expert picks realize that Creighton has proven to be more than just a two-man team.

Louisville counters with four double-digit scorers with each of them being transfers in their first season with the Cardinals. There are concerns about the availability of senior guard Reyne Smith as he was injured in the ACC title game. He looks to be good to go.

He’s BACK‼️ Reyne Smith will officially play vs #9 Creighton in the NCAA Tournament 👀 pic.twitter.com/F0rWvCv12b

— Louisville CBB (@Louisvillecbb) March 18, 2025

This could come down to the wire so when making March Madness expert picks, take the underdog from the Big East to cover.

Creighton vs Louisville March Madness Best Prop Bet

There are plenty of college basketball player prop bets to consider. Terrence Edwards averaged 25 points and 5.3 rebounds in the ACC tournament.

Creighton big man Ryan Kalkbrenner averaged 19 points and eight rebounds over his last eight NCAA tournament games. Go with the +114 college basketball odds for Kalkbrenner to have 34 combined points, rebounds and assists when making March Madness predictions.

Bet on Ryan Kalkbrenner 34+ points+rebounds+assists (+114)

Creighton vs Louisville How To Watch

• Game: Creighton (24-10) vs Louisville (27-7)
• Date/Time: Thursday, Mar. 20, 12:15 p.m. ET
• Location: Rupp Arena, Lexington, KY
• Creighton vs Louisville Live Stream: Fubo.Tv

Get the latest Creighton vs Louisville betting trends here.

More March Madness Picks, Predictions and Best Bets

• March Madness 2025: Creighton vs Louisville Same Game Parlay Picks March 20

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.