DePaul vs Creighton Prediction, Odds and College Basketball Picks: Take Under in Big East Quarterfinal, March 13
- Look for the DePaul vs Creighton game to land under 143 points.
- Double-digit underdog DePaul could be a best bet to cover 12.5 points.
- Make bank with our top NCAAB picks! Join with our promo code HUDDLE125.
DePaul vs Creighton College Basketball Best Bets



Creighton has some unfinished business after falling in the Big East quarterfinals as the No. 2 seed last year. The Bluejays won the two college basketball games with DePaul in the regular season by an average of 17 points.
Creighton is (+10000) in our March Madness odds. Good luck finding DePaul in the list. It’s hard to pick against Creighton in this matchup.
ONE HANDED TIP IN
1:03 2H | DePaul 70, Georgetown 64 pic.twitter.com/NHVuIHQ2tt
— DePaul Basketball (@DePaulHoops) March 13, 2025
DePaul vs Creighton Prediction Today
A year ago, DePaul headed into the Big East tournament after going 0-20 in conference play during the regular season. This DePaul team is playing at a higher level. However, Creighton has won by at least 10 points in each of its last nine games. Will that factor into the NCAAB expert picks?
DePaul has a slightly better record against the NCAA basketball odds as an underdog than Creighton does as a favorite. Go with Creighton to make it 23 wins in a row against DePaul when making March 13 college basketball picks, Score prediction: Creighton 75, DePaul 66
DePaul vs Creighton How to Watch
- Game: DePaul (14-18) vs Creighton (22-9)
- Date/Time: March 13, 7 p.m. ET
- Location: Madison Square Garden, New York
- DePaul vs Creighton Live Stream: TBS.com
Find DePaul vs Creighton betting trends here.
Top 2 DePaul vs Creighton Betting Picks
1. DePaul vs Creighton ATS Pick
DePaul covered in the last meeting with Creighton and is 4-0 against the college basketball spread in its last four games.
Tomorrow’s matchup is set. #GoJays pic.twitter.com/REyTsolETz
— Creighton Men’s Basketball (@BluejayMBB) March 13, 2025
Creighton is just 2-4-1 ATS in its last seven games. Playing after receiving an opening-round bye can be a little challenging even if the Bluejays are 5-3 ATS when having more rest than their opponents.
Go with DePaul to go enough to cover as 11.5-point underdogs when it comes to the DePaul vs Creighton best bets.
2. DePaul vs Creighton Over / Under
When looking at the college basketball trends, the game landed over in four of Creighton’s last six games. However, just two of Creighton’s last 10 games have finished over. That is just one of the reasons we like the DePaul vs Creighton game to land under 143 when making March 13 college basketball bets.
Bet on DePaul vs Creighton Under 143
DePaul vs Creighton Best Player Prop Bet
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Ryan Kalkbrenner Over 20.5 points (-113)
Ryan Kalkbrenner had 38 points and 21 rebounds in the two regular-season games against DePaul. He has made college basketball basketball news by scoring at least 20 points in three of his last four matchups with the Blue Demons.
When looking at the college basketball player prop options, take Kalkbrenner over 20.5 points.
Bet on Ryan Kalkbrenner Over 20.5 points (-113)
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
More College Basketball Expert Picks For March 13
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Question of the Day
Which team has a better record against the spread this season, DePaul or Creighton?
DePaul is 18-14 and Creighton is 14-17 against the spread this season.