Drake vs Texas Tech Odds, Prediction and March Madness Picks, March 22

Drake got plenty of help from Missouri to win its March Madness opener, with the Bulldogs turning 17 Missouri turnovers into 23 points to win its first NCAA Tournament game since 1971.

Texas Tech looks to avoid being eliminated by a No. 11 seed for the second tournament in a row. Dating back to 2002, the Red Raiders are 3-2 outright and 2-3 against the college basketball spread when facing a team seeded 11th. That could factor into the NCAA basketball championship odds.

Texas Tech is listed by the college basketball lines as the 7½-point favorite with -315 odds to win outright. Drake has +258 odds to advance to the Sweet 16.

Texas Tech is at +2800 in the March Madness betting odds. Drake comes in at +40000 in the championship odds. The Red Raiders are at +450 in the West Region title odds.

Drake vs Texas Tech Prediction Today March 22

My prediction

Texas Tech 70, Drake 64

Drake took it to Missouri from the opening tip to pull off one of the biggest first-round upsets. Don’t expect to see Texas Tech shoot 33% from the field or make 25% of its 3-pointers, as Missouri did. Drake is perfect against the college basketball spread as the underdog this season. Will that NCAA betting trend continue?

Texas Tech didn’t shoot the ball well in its March Madness opener but the Red Raiders still made 13 3-pointers. Texas Tech only turned the ball over seven times and that is the recipe for success for the Red Raiders.

Keep that in mind when making college basketball picks.

Top 3 Drake vs Texas Tech Betting Picks

My top picks

1. Drake vs Texas Tech ATS Pick: Drake (+7½)
2. Drake vs Texas Tech O/U Pick: Over 127
3. Drake vs Texas Tech best point-scorer bet: Drake’s Bennett Stiritz 18+ Points

My Analysis

Drake has done well against teams from the Power-4 conferences with wins over Kansas State, Miami and Vanderbilt. In the tournament opener, Drake made college basketball news with its victory over Missouri out of the SEC.

Bennett Stirtz was exceptional in Drake’s NCAA tournament win over Missouri. He got anywhere he needed with outstanding ball-handling skills and creativity, while flashing terrific shot-making prowess. Size, skill, feel, and pace look first-round pick caliber. Texas Tech up next pic.twitter.com/qgxJkQ0r0k

— Jonathan Givony (@DraftExpress) March 21, 2025

The total of 127 set by the BetUS sportsbook is an indication of the defense played by Drake as well as the preferred pace of play.

Drake vs Texas Tech March Madness Best Prop Bet

JT Toppin 9+ Rebounds (+102)

It was business as usual for Texas Tech’s JT Toppin in the tournament opener as the sophomore had 12 points and 11 rebounds in 31 minutes.

Appreciate all the support this season! Much love, Red Raider Nation. See you in Wichita! @MatadorClubOrg pic.twitter.com/i60DZi1asP

— JT Toppin (@j1izzle) March 20, 2025

Take the +102 odds for Toppin to have at least nine rebounds when considering college basketball prop bets.

Bet on JT Toppin 9+ Rebounds (+102)

Drake vs Texas Tech How To Watch

• Game: Drake (31-3) vs Texas Tech (26-8)
• Date/Time: Saturday, March 22, 6:10 p.m. ET
• Location: INTRUST Bank Arena, Wichita, KS
• Drake vs Texas Tech Live Stream: fubo.tv

Check out the Drake vs Texas Tech stats here.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.