Duke vs Clemson Prediction and Picks: Bet Huge ACC Showdown to Land Over 133.5 On February 08

Duke is rolling right along as the Blue Devils take a 16-game winning streak into a road matchup with Clemson on Saturday. Seven of those wins have come on the road.

None of the players for either team were born the last time Duke was listed by the college basketball odds as the underdog against Clemson. The Blue Devils are favored for the 43rd consecutive game against the Tigers.

The college basketball lines list Duke as a 6.5-point favorite as the Blue Devils look to remain perfect as a road favorite this season. Duke has won 25 of the last 30 meetings with Clemson. However, the Tigers pulled off upsets in two of their last three home games against the Blue Devils.

When looking at the college basketball futures odds, Duke is tied with Auburn at +400 for the shortest odds of winning March Madness. The championship odds for Clemson have moved from +12500 to +10000 since the start of the season.

Check out our best Duke vs Clemson expert picks ahead.

Duke vs Clemson How To Watch

• Game: Duke (20-2, 12-0 ACC) vs Clemson (18-5, 10-2)
• Date/Time: Saturday, Feb. 8, 6:30 p.m. ET
• Location: Littlejohn Coliseum, Clemson, SC
• Duke vs Clemson Live Stream: TBS.com

Find Duke vs Clemson betting trends here.

3 Duke vs Clemson Bets You Should Make

1. Duke vs Clemson Over 133.5

The first thing that jumps out when looking at the Duke vs Clemson trends is that four of the last five meetings between these two teams finished under the total. However, each of the last three matchups between the Blue Devils and the Tigers with the total under 135 saw the game land over that total.

BetUS Sportsbook has the total of Saturday’s game between the ACC rivals set at 133.5. Only once in the last 12 meetings has there been a lower total in a game between Duke and Clemson.

Primetime road test at Clemson 😈 pic.twitter.com/i6UsrOFuGP

— Duke Men’s Basketball (@DukeMBB) February 8, 2025

Duke has scored at least 80 points in four of its last five road games, while Clemson is averaging 82.8 points in its last five home games.

Duke’s Cooper Flagg and Clemson’s Chase Hunter are two of the top six scorers in the ACC. Both stars have plenty of help, so take the game to land over when making your NCAA basketball bets.

Bet On Duke vs Clemson Over 133.5

2. Duke -6.5

Clemson is a home underdog for just the second time this season. The Tigers clawed their way past Kentucky for a 70-66 victory in the other instance. It was the fourth consecutive time that Clemson covered against the college basketball spreads as the home underdog.

CU in Littlejohn tonight!#ClemsonGRIT 🆚 Duke
🕡 6:30 PM
📺 ESPN
📻 Clemson Athletic Network
🟠 ORANGE OUT pic.twitter.com/WEufPjb1F5

— Clemson Basketball (@ClemsonMBB) February 8, 2025

Duke has been favored on the road six times this season and covered in five of those games. The Blue Devils have won all but one ACC game this season by more than seven points. We’re going to go with the Blue Devils to not only win outright to stay undefeated in ACC play, but to find a way to cover as well.

Bet Duke -6.53

3. Duke G Tyrese Proctor Over 9.5 Points (-130)

Much of the focus for No. 2 Duke is on freshmen Flagg and Kon Knueppel, and with good reason. However, don’t forget about veteran guard Tyrese Proctor when looking at the college basketball player props.

Proctor is averaging 16.5 points in his last two games while shooting 40% from 3-point range. He had 18 points and four 3-pointers the last time he faced Clemson and is averaging 17.5 points in his two career matchups with Clemson.

Go with Proctor at -130 to go over 9.5 points when making your college basketball bets.

Bet On Tyrese Proctor Over 9.5 Points (-130)

Duke vs Clemson Prediction

Duke 74, Clemson 65

Questions of the Day

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.