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Duke vs Syracuse Prediction and Picks: Make Over 143 Best Bet on Feb 5
- Look for the Duke vs Syracuse game to land over 143 points.
- Take Syracuse (+17) cover as a double-digit home underdog.
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The days of Syracuse feeling like a lock to win at home are gone, but the Orange should have quite the crowd waiting for the second-ranked Duke Blue Devils as Syracuse goes after its ninth home win. This will be the 18th meeting in a row when Duke is favored against Syracuse.
The college basketball lines list Duke as a 17-point favorite as the Blue Devils look to remain perfect as a road favorite this season and also beat Syracuse for the 10th time in a row.
When looking at the college basketball futures odds, Duke is tied with Auburn at +380 for the shortest odds of winning March Madness. The championship odds for Syracuse have moved from +12500 to +100000 since the start of the season.
Check out our best Duke vs Syracuse expert picks ahead.
Duke vs Syracuse Prediction
Duke 82, Syracuse 66
Duke vs Syracuse How To Watch
- Game: Duke (19-2, 11-0 ACC) vs Syracuse (10-12, 5-4)
- Date/Time: Tuesday, Feb. 5, 7 p.m. ET
- Location: JMA Wireless Dome, Syracuse, NY
- Duke vs Syracuse Live Stream: tbs.com
Find Duke vs Syracuse betting trends here.
3 Duke vs Syracuse Bets You Should Make
1. Bet Over 143
Duke is one of three ACC teams that is averaging at least 80 points per game. The Blue Devils will face a Syracuse team allowing more points per contest than any other team in the ACC other than Miami.
wheels up to Syracuse ✈️ pic.twitter.com/dzGkyLSjym
— Duke Men’s Basketball (@DukeMBB) February 4, 2025
Duke has hit more 3-pointers than any other ACC team this season after going 10-for-20 from distance the last time out in a convincing win over North Carolina.
Even though just two of the last 10 games between Duke and Syracuse went over the total, take the game to land over when making Duke vs Syracuse bets.
Bet On Duke vs Syracuse to Go Over 143
2. Bet Syracuse (+17) To Cover
It isn’t only years but decades since Syracuse has been such a heavy underdog at home. Dating back to 2008, the Orange haven’t been listed by the college basketball odds as a double-digit underdog at their spacious home court. The line opened with Duke favored by 18.5 points. With the early money coming in on Syracuse, it has moved to 17. Even that number is sure to generate plenty of action.
When looking at the college basketball betting trends, Syracuse is just 1-4 this season as a home underdog with the Orange covering in only two of those games. Duke has won each of its five matchups as the road favorite with a 4-1 ATS mark in those games.
Syracuse has covered in each of its last two games as the underdog at home with a hard-fought loss to Pittsburgh and a win over Notre Dame. Obviously, this Duke team will present more challenges for the Orange. When making Duke vs Syracuse picks, go with the home team to find a way to hang around and cover.
3. Duke’s Kon Knueppel to Go Over 13.5 Points (-130)
It is tempting to roll with freshman phenom Cooper Flagg in the college basketball player props whenever the Duke Blue Devils hit the court. Feel free to keep going back to that bet as Flagg has four consecutive 20-point games to go with at least 20 points, six rebounds and six assists in three of his last six games.
We’re looking for another option. Fellow freshman Kon Knueppel is averaging 18.7 points and 6.3 rebounds in his last three games, per Duke vs Syracuse stats, and has picked things up since being held scoreless in a convincing win at Boston College.
What a night for the freshman! 👏
Kon Knueppel led No. 2 Duke in scoring, dropping 22 points against rival UNC.@DukeMBB | @DukeATHLETICS | #𝕿𝖍𝖊𝕭𝖗𝖔𝖙𝖍𝖊𝖗𝖍𝖔𝖔𝖉 | @crushsoda pic.twitter.com/4bVeBEdebG
— ACC Digital Network (@theACCDN) February 2, 2025
Take a look at the -130 odds for Knueppel to go over 13.5 points. Another option could be Duke junior forward Maliq Brown, who returns to a familiar arena after spending his first two seasons playing for Syracuse. His best scoring game last season came when he had 26 points against Duke.
Bet On Kon Knueppel to Go Over 13.5 Points (-130)
Questions of the Day
Which team has a better record against the spread this season, Duke or Syracuse?
Duke is 13-8 and Syracuse is 12-9-1 against the spread this season.
What happened the last time that Duke played at Syracuse?
Tyrese Proctor had eight points and six assists as Duke shot 54.5% from the field in a 77-55 win in 2023 as a 1-point favorite.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
