Gonzaga vs Houston Odds, Prediction and March Madness Picks March 22

It is hard to believe that this will be the first meeting between Gonzaga and Houston. The WCC and Big 12 tournament champions square off with a trip to the regionals on the line for two teams accustomed to being among the favorites to win March Madness.

Gonzaga scored the first 13 points in a win over Georgia while Houston would have topped SIU Edwardsville by double digits even if the Cougars didn’t score in the second half. Expect a more competitive matchup when the teams meet in the second round.

Houston, the No. 1 seed in the Midwest, is listed by the college basketball lines as the 5-point favorite with -218 odds to win outright. Gonzaga has +186 odds to advance to the Sweet 16 for the 10th time in a row.

Round 2⃣ pic.twitter.com/IiEc0OnPBi

— Gonzaga Basketball (@ZagMBB) March 21, 2025

Houston is at +600 in the March Madness betting odds. Gonzaga comes in at +3000 in the championship odds. Houston (+125) and Gonzaga (+450) are among the front-runners in the Midwest Region title odds.

Gonzaga vs Houston Prediction Today March 22

Houston 73, Gonzaga 69

Most of the attention will be focused on Houston’s stifling defense that is rated second by the Pomeroy basketball database going up against Gonzaga’s top-10 offense. The game could be decided on the other end of the court as Houston is just outside the top 10 in offensive rating.

It is hard to pick against Houston to win outright. However, Gonzaga has plenty of players who know how to deliver at this time of the season so the Bulldogs could be worth considering as the underdog when making college basketball picks.

Top 3 Gonzaga vs Houston Betting Picks

My top Picks

1. Gonzaga vs Houston ATS Pick: Gonzaga (+5)
2. Gonzaga vs Houston O/U Pick: Over 140
3. Gonzaga vs Houston Best Point-scorer Bet: Houston’s L.J. Cryer Over 15.5+ Points (-127)

My Analysis

Gonzaga is just 3-3 against ranked teams this season, per NCAA betting trends, and many of the struggles have come on the offensive end. The Bulldogs averaged just 61 points in the three meetings with WCC rival Saint Mary’s. Sorry Gonzaga fans, but Houston is a better defensive team than the Gaels.

The 140-point total set by the BetUS sportsbook is a little low for a typical Gonzaga game but with the way Houston gets after it on the defensive end, why not go with the game to land over the NCAA basketball odds total?

There are plenty of seniors, including Cryer, in key roles for both teams so perhaps that will help Gonzaga cover as the 5-point underdog in one of the more intriguing March Madness games on Saturday.

Gonzaga vs Houston March Madness Best Prop Bet

Milos Uzan 2+ Made 3-pointers (-112)

Milos Uzan doesn’t get as much attention and generate the same level of March Madness news as some of his Houston teammates. That’s a shame because he can do it all for the Cougars.

Halftime in Wichita, Kan.

L.J. Cryer: 15 points
Milos Uzan: 14 points pic.twitter.com/Iz3Oh7aBcu

— Joseph Duarte (@Joseph_Duarte) March 20, 2025

In his last four games, Uzan is 9 of 14 from 3-point range. When considering college basketball prop bets, take the -112 odds for Uzan to have at two 3-pointers.

Bet on Milos Uzan 2+ Made 3-pointers (-112)

Gonzaga vs Houston How to Watch

• Game: Gonzaga (26-8) vs Houston (31-4)
• Date/Time: Saturday, March 22, 8:40 p.m. ET
• Location: INTRUST Bank Arena, Wichita, KS
• Gonzaga vs Houston Live Stream: fubo.tv

Check here for Gonzaga vs Houston stats.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.