Houston vs Duke Odds, Final Four Prediction and College Basketball Picks

Duke and Houston were among the five teams with the shortest odds of winning the national championship when the 2024-25 college basketball season began. Despite some injuries and other challenges, they have lived up to the expectations.

L.J. Cryer, a member of Baylor’s 2020-21 national championship team, and Duke star freshman Cooper Flagg are the headliners. However, other players could offer tempting March Madness odds.

First full day from the Final Four#ForTheCity x #FinalFour pic.twitter.com/T9jDi3sEqB

— Houston Men’s Hoops 🏀 🐾 (@UHCougarMBK) April 3, 2025

The college basketball betting lines list Duke as the 5-point favorite. Houston offers some value at +218 on the moneyline as the underdog.

Duke is at -110 in the March Madness winner odds. Houston comes in at +450 in the championship odds. Duke star Cooper Flagg has even odds to be named the Most Outstanding Player of the Final Four.

Houston vs Duke Prediction Today April 5

Duke 68, Houston 64

It is hard to believe that the Sweet 16 matchup in the 2024 NCAA Tournament was the first meeting between Duke and Houston. They get to do it again in Saturday’s second national semifinal.

While I expect more scoring than the 105 points the teams combined for in the 2024 meeting, these are two outstanding defensive teams playing for a shot to reach the national title game. It may not be an artistic masterpiece.

Keep that in mind when considering March Madness expert picks.

Top 3 Houston vs Duke Betting Picks

1. Houston vs Duke ATS Pick: +5 points
2. Houston vs Duke O/U Pick: Under 137 points
3. Houston vs Duke best player prop: Houston’s L.J. Cryer to have 3+ Assists (+120)

My Analysis

Houston covered against the college basketball spread in its only game as the underdog this season while Duke is delivering 65% of the time as a favorite.

This just feels like a game where both teams struggle to pull away. Going with Houston to cover as the underdog could be the way to go when making March Madness bets.

Houston has seen eight of its last 11 games go under the total. When making NCAAB picks today, tread carefully when looking at the 137-point total as Duke hasn’t had a game with a total under 140 since mid-February.

Houston vs Duke Final Four Best Prop Bet

• Cooper Flagg 34+ Points, Rebounds and Assists (+112)

Do you really think I would pick somebody other than Duke freshman Cooper Flagg?

“I think he’s always looked like the number one pick in the draft.”

Duke head coach Jon Scheyer talks about unlocking Cooper Flagg’s potential this season 💪 pic.twitter.com/04n23H59sg

— ESPN (@espn) April 3, 2025

Per NCAA betting tips, Flagg is averaging 19.5 points, 7.3 rebounds and 5.3 assists in Duke’s first four March Madness games. Go with the +106 odds for Flagg to have 34+ combined points, rebounds and assists when making NCAAB expert picks.

Houston vs Duke How to Watch

• Game: Houston (34-4) vs Duke (35-4)
• Date/Time: Saturday, April 5, 8:49 p.m. ET
• Location: Alamodome, San Antonio, TX
• Houston vs Duke Live Stream: Fubo.tv

Take a look at the Houston vs Duke stats here.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.