Lay Points With UConn vs DePaul
It will be the best and the worst teams in the Big East squaring off at Wintrust Arena when top-ranked UConn hits the road to take on DePaul before the huge weekend matchup against Marquette. The Huskies are a road favorite for just the second time this season according to the NCAAB expert picks.
UConn has won 17 games in a row against DePaul, although the last two road games have been decided by seven points or less. This is the fifth time in a row that the Huskies are listed by the college basketball spread as a double-digit favorite – the defending national champions are listed as a 24.5-point favorite.

UConn is fourth in the NCAAB NET rankings. DePaul is 0-10 in Quad 1 games and the Blue Demons are tied with Vanderbilt for the most Quad 1 losses in the country. The Huskies received 69 first-place votes to remain at No. 1 in the Associated Press and the USA Today coaches poll.
When it comes to the odds of winning March Madness, UConn (+650) is first in the odds of winning the national title.
Keep on reading for more on the matchup between UConn and DePaul.
UConn vs DePaul Game Information
- Game: UConn (22-2, 12-1 Big East) vs DePaul (3-20, 0-12 Big East)
- Date/Time: Wednesday, Feb. 14, 9 p.m. ET
- Location: Wintrust Arena, Chicago, IL
- UConn vs DePaul Live Stream: TBS.com
UConn is 5-1 outright as a road favorite with the Huskies covering in four of those matchups. DePaul is 0-9 as a home underdog with the Blue Demons covering in only one of those games.
Top Dogs with a big week ahead.#Everything pic.twitter.com/heB030tSry
— UConn Men’s Basketball (@UConnMBB) February 12, 2024
The NCAA basketball lines have moved from 23½ to 24½. UConn has covered in just two of its last six games as a 20-point favorite. One of those games when the Huskies did cover came against DePaul. The Blue Demons have failed to cover in their last three games as a double-digit underdog.
UConn vs DePaul Odds and Spreads
UConn vs DePaul Betting Trends
- UConn is 22-1 this season as the favorite.
- DePaul has lost each of its 17 games as an underdog.
- DePaul is just 4-9-1 against the spread at home.
- The Huskies have covered in 12 of their last 14 matchups with DePaul.
- UConn is 4-1 against the Las Vegas NCAAB odds in its last five games played in February.
- DePaul is 3-6 ATS in its last nine games.
- The Blue Demons have lost six straight home games to UConn.
- DePaul has covered in only four of the last 12 games against Big East teams.
UConn vs DePaul ATS Pick: UConn -24½
It isn’t often that a team with a double-digit winning streak meets a team with more than 10 losses in a row. That is the scenario for this matchup and why the college basketball spread is so high.
With a huge game coming up against Marquette, will UConn be totally focused on dispatching of a dreadful DePaul team? In UConn’s last game, head coach Dan Hurley called a timeout late in the game against Georgetown with a 25-point lead because some of the players did not hustle back on defense so expect him to have the Huskies ready for this matchup.
DePaul would have its hands full against UConn with a full roster available to play. However, DePaul lost reserve guard Caleb Murphy for the season with a wrist injury. Leading scorer Chico Carter hasn’t played since a Nov. 17 loss to Providence and Keyondre Young is questionable.
UConn point guard Tristen Newton has been dealing with a hand injury but he should be good to go for this game.
DePaul made Marquette work for a 13-point win the last time a ranked team came to Wintrust Arena. However, the Blue Demons have lost their last three games by 33, 26 and 28 points – and none of those teams are as good as the Huskies.
UConn vs DePaul Over/Under Pick: Over 141½
This could be a game where the Huskies get to work in some players in the second half who normally don’t get much playing time and that could give DePaul a chance to get some stuff done on offense.
UConn has at least 77 points in four of its last five road games and had 89 points at Georgetown the last time out. Don’t be surprised to see a similar number go up on the scoreboard in this matchup when looking at the best college basketball bets today.
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UConn vs DePaul Prediction
Questions Of The Day
How has DePaul fared against the spread at home against UConn?
DePaul has covered in just one of its last seven home games against UConn.
Which team has the best record against the spread this season heading into the UConn-DePaul matchup?
UConn is 14-10 against the spread and that is tied for the third-best mark in the Big East. DePaul is last in the conference with a 7-15-1 mark against the college basketball spread,
The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.