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Louisville vs Duke Prediction, Odds and College Basketball Picks: Take Cardinals +6 in ACC Title Clash on March 15
- Look for the Louisville vs Duke game to land under 147 points.
- Duke G Kon Knueppel is a good bet to score over 17.5 points.
- Make bank with our top NCAAB picks! Join with our promo code HUDDLE125.
Louisville vs Duke College Basketball Best Bets
Louisville had few answers for Duke’s all-everything freshman Cooper Flagg in the lone meeting between these conference rivals in the regular season. But with Flagg sidelined with an ankle injury, the Cardinals won’t need to contend with the National Player of the Year front-runner in the ACC title game on Saturday night.
Duke (+350) is tied with Auburn for the shortest March Madness betting odds. Louisville is tied for 24th at +10000 in the championship odds.
Louisville is 5-1 against the college basketball spread as the underdog this season, while Duke is 20-12 ATS when listed by the BetUS Sportsbook as the favorite.
Louisville vs Duke Prediction Today
Duke has won its last six meetings with Louisville, with five of those wins coming by double digits. The lone meeting in the regular season came on Dec. 8, so it is hard to read too much into what happened in that contest.
When making your college basketball picks, keep in mind that Duke has won 10 games in a row, while Louisville comes in on an 11-game winning streak. Score prediction: Duke 76, Louisville 72.
Louisville vs Duke How to Watch
- Game: Louisville (27-6) vs Duke (30-3)
- Date/Time: Saturday, March 15, 8:30 p.m. ET
- Location: Spectrum Center, Charlotte, NC
- Louisville vs Duke Live Stream: TBS.com
Find Louisville vs Duke betting trends here.
Top 2 Louisville vs Duke Betting Picks
1. Louisville +6 (-110)
It hasn’t been pretty for Louisville in the ACC tournament, with wins by just two and three points. The Cardinals are 6-1 in games decided by six points or less this season.
Duke proved it was not a one-person team in getting past a red-hot North Carolina team without Flagg on the court.
Duke star Cooper Flagg was helped to the locker room after suffering an apparent leg injury during the Blue Devils’ quarterfinal matchup in the ACC Tournament.
🎥 @espn pic.twitter.com/ZtBijM9y9D
— The Athletic (@TheAthletic) March 13, 2025
He is not expected to play in the conference tournament title game, and that is enough to go with the Cardinals to cover as the six-point underdogs as the top Louisville vs Duke best bet.
2. Louisville vs Duke Over 147 (-110)
Louisville had three starters saddled with foul trouble, and that might have played a role in the Cardinals missing 16 of their 22 shots from 3-point range in the ACC semifinal win over Clemson on Friday. That would be a problem if it happens again in the ACC title contest.
Go with the ACC championship game to land over 147 points when it comes to the NCAA basketball expert picks.
Bet On Louisville vs Duke Over 147 (-110)
Louisville vs Duke Best Player Prop Bet
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Kon Knueppel Over 17.5 Points (-121)
Flagg is not the only dynamic freshman for the Blue Devils this season, as Kon Knueppel is averaging 22.5 points, 4.5 rebounds and 5.5 assists in the ACC tournament.
When looking at the college basketball player prop options, take Knueppel at -121 to go over 17.5 points.
Bet On Kon Knueppel Over 17.5 Points (-121)
Questions of the Day
Which team has a better record against the spread this season, Louisville or Duke?
Duke is 21-12 and Louisville is 20-13 against the spread this season.
How many ACC tournament titles have Louisville and Duke won?
Duke has won a record 22 ACC tournament championships, while Louisville is in the ACC final for the first time.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
