March Madness 2025: Creighton vs Louisville Same Game Parlay Picks March 20

Louisville and Creighton just made it to the championship game in their conference tournament and their reward is to be in the 8 vs 9 game in the South Region with plenty of money coming in via March Madness bets. At least Louisville gets to stay in the state of Kentucky with the first-round game at Rupp Arena.

The teams haven’t met since the 1999 NCAA tournament so there won’t be many trends to rely on when making college basketball picks.

College basketball betting odds have Louisville as a 2½-point favorite with -145 odds to win outright. Creighton is at +125 to come away with the victory on Thursday to set up a possible second-round clash with top-seeded Auburn. That will be a challenge with Auburn among the favorites in our odds for March Madness.

Creighton vs Louisville Free March Madness Parlay Picks Today (March 20)

• Creighton ATS +2½

When I look at these two teams and how they played in their conference tournaments, it feels like a game that could go either way. When making March Madness picks, taking the underdog to cover is never a bad idea when two teams from elite conferences get together in March Madness.

We’ve arrived #GoCards pic.twitter.com/acnMV44Z1C

— Louisville Men’s Basketball (@LouisvilleMBB) March 19, 2025

It’s hard to go against the March Madness experience that players like Steven Ashworth and Ryan Kalkbrenner bring to the table. That will factor into the expert NCAAB picks.

Bet Creighton +2.5 (-105)

• Creighton vs Louisville Under 145.5

Louisville faced two teams in the March Madness bracket with the Cardinals scoring 76 points against Clemson and 62 versus Duke.

Creighton has no problem running the shot clock down and trusting that the senior-laden team can get quality shots.

A March Madness prediction to consider is for the Creighton vs Louisville matchup to land under 145.5 points.

Bet Louisville vs Creighton game under 145.5

• Jamiya Neal 24+ Points, Rebounds and Assists (-110)

Jamiya Neal made NCAA basketball news for his late dunk against UConn in the Big East semifinals that generated an immediate reaction from Huskies’ point guard Hassan Diarra. He could be known for more than that by the time this game is over.

NEAL WITH THE EXCLAMATION POINT 🔥 @jamiyaneal_ x @BluejayMBB pic.twitter.com/yR5mB6diQU

— FOX College Hoops (@CBBonFOX) March 15, 2025

Neal averaged 16 points, 6 rebounds and 4.5 assists against UConn and St. John’s in Creighton’s last two games. The bigger the game, the better the Arizona State transfer plays. When looking at the college basketball player prop odds, jump on the -110 odds for Neal to have at least 24 combined points, rebounds and assists when making March Madness best picks.

Bet Jamiya Neal to have 24+ points, rebounds and assists (-110)

• Neither Team to Lead by 14.5+ Points (-157)

This feels like a game that could go back and forth as both the Bluejays and Cardinals head into the first-round matchup with plenty of confidence.

Neither team figures to get rattled if faced with an early deficit so go with the -157 odds for neither team to lead by more than 14.5 points in the game.

Bet neither team to lead by 14.5+ points (-157)

Creighton vs Louisville How to Watch

• Game: Creighton (24-10) vs Louisville (27-7)
• Date/Time: Thursday, Mar. 20, 12:15 p.m. ET
• Location: Rupp Arena, Lexington, KY
• Creighton vs Louisville Live Stream: Fubo.tv

Get updated Creighton vs Louisville injuries here.

More March Madness Picks, Predictions and Best Bets

• Creighton vs Louisville Odds, Prediction and March Madness Picks March 20

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets