March Madness 2025: Ole Miss vs Michigan State Same Game Parlay Picks March 28

The first of Friday’s Sweet 16 games will tip off at State Farm Arena in Atlanta when Ole Miss looks to end the tournament run of Michigan State in the first meeting between the programs since 1999.

There were 24 teams listed by the college basketball futures odds with shorter odds of reaching the Final Four than Ole Miss when the season began.

🔜 pic.twitter.com/J8kKr9hYmG

— Ole Miss Men’s Basketball (@OleMissMBB) March 27, 2025

The March Madness odds list Michigan State as the 3.5-point favorite with -170 odds to win outright. Ole Miss is priced at +146 to reach the Elite Eight for the first time in program history.

Ole Miss vs Michigan State Free March Madness Parlay Picks Today (3/28)

• Michigan State ATS Pick -3.5

It has been six years since Tom Izzo got Michigan State into the Elite Eight and next up is a matchup with an Ole Miss team that has eliminated a blue-blood North Carolina program and third-seeded Iowa State.

Sweet Sixteen 🔜 pic.twitter.com/05DY4g4NJE

— Michigan State Men’s Basketball (@MSU_Basketball) March 26, 2025

Ole Miss has covered in 10 of its 16 games when listed by the BetUS sportsbook as the underdog this season. However, Michigan State was among the national leaders with a 19-9 ATS record as the betting favorite. That is something to consider when looking at the March Madness lines.

The Spartans were tested by New Mexico in the second round but responded with key plays on both ends of the court to advance to the regionals. Take Michigan State to cover when looking at the March Madness best picks.

Bet Michigan State -3.5

• Ole Miss vs Michigan State Over/Under Pick

Michigan State is last among Big Ten teams this season with just 11 games going over the total, per NCAA betting trends. Ten of the 16 games when Ole Miss has been the underdog landed under the total.

The March Madness betting line total of 143 is the second lowest among the eight regional semifinals. Ole Miss is coming off a 91-point effort against Iowa State. Points should be a little harder to come up in this win. Go with the game to finish under 143 when considering March Madness best bets.

Bet Ole Miss vs Michigan State Game Under 143

• Player Prop Pick: Sean Pedulla 16+ Points

Sean Pedulla has certainly been consistent. In his lone NCAA tournament game in his three seasons at Virginia Tech, he had 19 points. He scored 20 points in the matchups with North Carolina and Iowa State.

Pedulla also has 13 assists and six steals in the two games. I’ll go with the -103 odds for Pedulla to have at least 16 points in this NCAA basketball game.

Bet Sean Pedulla to have 16+ Points (-103)

• Ole Miss vs Michigan State Game Prop Pick

Michigan State had no issues pulling away from Bryant in its March Madness opener. It was a different story against New Mexico.

Ole Miss had to play plenty of elite teams during SEC play so the Rebels should be able to hang around. When making Ole Miss vs Michigan State best bets, go with the largest lead in the game to be under 14.5 points.

Bet Largest Lead to Go Under 14.5 Points (-139)

Ole Miss vs Michigan State How to Watch

• Game: Ole Miss (24-11) vs Michigan State (29-6)
• Date/Time: Friday, March 28, 7:09 p.m. ET
• Location: State Farm Arena, Atlanta, GA
• Ole Miss vs Michigan State Live Stream: Fubo.Tv

Check out the Ole Miss vs Michigan State injury report here.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets

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