March Madness Final Four: Houston vs Duke Same Game Parlay Picks, April 5th

Buckle up as the best defensive team in men’s college basketball prepares to clash with the expected top pick in the 2025 NBA Draft in a March Madness semifinal featuring contrasting styles.

This is the second season in a row that Duke and Houston will meet in March Madness. The Blue Devils won 54-51 when listed by the BetUS sportsbook as the 4.5-point underdog in the Sweet 16.

The March Madness odds list Duke as the 5-point favorite with -260 odds to win outright. Houston is priced at +218 to reach the national title game for the first time since 1984. Duke is favored to win it all in the NCAA basketball futures odds.

Houston vs Duke free Final Four Parlay Picks Today, April 05

1. Houston ATS +5 (-110)

Duke has won three of its four games in the NCAA Tournament by at least 20 points. The lone exception was a matchup with Arizona out of the Big 12 in the Sweet 16 with the Blue Devils winning 100-93. Keep that in mind when it comes time to bet on March Madness.

Houston won the Big 12 regular-season title by four games and then captured the Big 12 tournament. The Cougars take a 17-game winning streak into the national semifinal, per Houston vs Duke stats.

Is Duke, player-for-player, the most talented team #Houston has seen this season?

“On paper, yeah,” said J’Wan Roberts to me earlier today.
“I feel like once we come in with that defensive mentality it’s going to be a different ballgame.”@KHOU pic.twitter.com/F3Es1Q5wiS
— Jason Bristol (@JBristolKHOU) April 2, 2025

I won’t be surprised to see Duke advance to the national title game. Houston to cover against the college basketball lines is worth a shot for those making online bets.

Bet Houston ATS +5

2. Over/Under Pick: Houston vs Duke Game Under 137 (-110)

Three of Houston’s four games in the NCAA Tournament went under the sports betting odds total. Houston held a talented Tennessee team to 50 points and 29% shooting in the Elite Eight. Now comes a greater test as Duke is first in the Pomeroy basketball database in offensive rating.

The Blue Devils are also in the top five in defensive rating and that part of the deal with the freshmen-laden ACC champions often gets overlooked.

I’ll take the game to go under 137 when making March Madness picks.

Bet Houston vs Duke Game Under 137

3. Player Prop Pick: Emanuel Sharp Over 12.5 Points (-117)

Emanuel Sharp got off to a slow start in the NCAA tournament with a total of 20 points in Houston’s wins over SIU Edwardsville and Gonzaga. As the stakes have gotten higher, Sharp has been more aggressive looking for his own shot with 17 and 16 points in the last two games.

ALL THE HATS AND TOWELS FOR EMANUEL SHARP 😅 pic.twitter.com/lVYg4ZETL2

— CBS Sports (@CBSSports) March 30, 2025

Sharp averaged 20.7 points in the Big 12 tournament.Take a look at the -117 odds for Sharpe to go over 12.5 points as a tempting option as part of the NCAAB parlay picks.

Bet Emanuel Sharp Over 12.5 Points (-117)

4. Game Prop Pick: Houston vs Duke Game to be Under 14.5 Points (-110)

Points could be hard to come by in this matchup between the ACC and Big 12 champions. Duke has found a way to pull away from its opponents during this year’s March Madness. It might be harder to accomplish that feat against the Cougars.

When making college basketball picks, take the -110 odds for the largest lead in the game to be less than 14.5 points.

Bet the Biggest Lead in the Houston vs Duke Game to be Under 14.5 Points (-110)

Houston vs Duke How to Watch

• Game: Houston (34-4) vs Duke (35-4)
• Date/Time: Saturday, April 5, 8:49 p.m. ET
• Location: Alamodome, San Antonio, TX
• Houston vs Duke Live Stream: Fubo.tv

Check out the Houston vs Duke injury updates.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.