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March Madness Predictions: Who Will Win NCAA Tournament?
- Florida (+375) is a solid pick to win March Madness.
- Tennessee offers good value to win the Midwest at +230
- Make bank with our top NCAAB picks! Join with our promo code HUDDLE125.
The March Madness field has been cut from 68 to 16 teams. Along the way, we have had upsets, bad beats, unforgettable moments and bracket-busting results. Hopefully, your bracket isn’t completely ruined because the best could be yet to come in the NCAA men’s basketball tournament.
With UConn’s loss to Florida, there will be a new champion crowned. The winners of the last eight national championships have either been sent home or failed to get into the field of 68.
Eight of the 10 teams with the shortest odds of winning March Madness advanced to the Sweet 16 with Arkansas the only double-digit seed to survive and advance so far.
Duke (+225) and Florida (+375) have the shortest odd to win March Madness with Auburn (+500) and Houston (+500) not far behind in the NCAAB championship odds.
BetUS has you covered with game previews, prop picks and parlays to consider as the tournament gets going again on Thursday with the BetUS sportsbook listing Alabama, Duke, Florida and Texas Tech as the favorites.
Top 3 March Madness Sweet 16 Analysis, Predictions
1. Hail To The SEC Teams
Looking back, having 14 teams from the SEC might have been a little much. However, half of those teams have moved on to the regionals and that has never been done before as the SEC has made college basketball news.
THE SWEET 16 IS LOCKED IN 🔒
RT IF YOUR SCHOOL IS STILL DANCIN’ 🕺#MarchMadness pic.twitter.com/DImvsyNm72
— NCAA March Madness (@MarchMadnessMBB) March 24, 2025
Of course, realignment has resulted in power conferences being larger than ever before.
Four of the seven remaining SEC teams are favored in the regional semifinals. There could be all SEC regional finals in the Midwest, South and West regions.
According to the college basketball futures odds, Duke (-200) is the favorite to represent the East in the Final Four, Houston (-120) is favored in the Midwest, Auburn (-140) has the shortest odds in the South, Florida (-130) leads the way in the West.
An all-SEC matchup is on top in the Sweet 16 when Tennessee squares off with Kentucky. The Vols are -4,5 favorites despite losing both regular-season matchups, per Kentucky vs Tennessee stats.
Value Bet: Tennessee (+230) to win Midwest Region
2. Duke Still Tops Best March Madness Odds
Looking at the championship odds from the beginning of the season, UConn was tied with Duke at +900 in the March Madness title odds. When looking at the NCAAB expert picks, Duke is still looking good to cash in.
SWEET SIXTEEN BOUND pic.twitter.com/raMHzyCJcG
— Florida Gators Men’s Basketball (@GatorsMBK) March 23, 2025
The Huskies gave it everything they had but fell short in the second round against a talented Florida team in one of the more compelling NCAA basketball games in this year’s tournament.
BYU (+7500), Ole Miss (+7500) and Maryland (+8000) had the longest championship odds in the college basketball betting line at the start of the season among the 16 remaining teams.
Bet: Duke (-200) to Win East Region
3. ATS Record Another Reason to Bet Florida
Eight games are being played on either Thursday and Friday as the field gets sliced to the Elite Eight.
Here’s a quick look with the team’s record against the college basketball spread included to help those who bet online make their picks.
- BYU (22-13) vs Alabama (20-15), Thursday 7:09 p.m. ET
- Maryland (18-16-1) vs Florida (26-10) Thursday, 7:39 p.m. ET
- Arizona (19-17) vs Duke (24-12), Thursday 9:39 p.m. ET
- Arkansas (16-18-1) vs Texas Tech (18-17), Thursday 10:09 p.m. ET
- Ole Miss (18-16-1) vs Michigan State (24-10-1), Friday 7:09 p.m. ET
- Kentucky (18-17) Tennessee (19-17), Friday 7:39 p.m. ET
- Michigan (18-18) Auburn (18-16-1), Friday 9:39 p.m. ET
- Purdue (19-16-1) vs Houston (19-16-1), Friday 10:09 p.m. ET
Duke (-9) is the heaviest favorite with Ole Miss (+3) the best of the underdog bets. The totals range from 132.5 for the Purdue-Houston clash to 175 when BYU meets up with Alabama.
Auburn and BYU lead the Sweet 16 teams with 21 games landing over the total, one more than Arizona, Purdue and Texas Tech. Michigan State has seen 24 games land under with Houston and Tennessee next up with 20 matchups going under the total, per NCAA betting trends.
Florida, which is 26-10 ATS, is -6.5 against Maryland in the next round and -130 to win the West. After escaping an upset bid by UConn, the Gators remain the college basketball prediction to win it all.
Championship Pick: Florida (+375)
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
Questions of the Day
Which No. 2 seed has the best odds of winning the national title?
Alabama and Tennessee are priced at +1600 in the odds of winning March Madness.
When does the Final Four begin?
The national semifinals will be on April 5 at the Alamodome in San Antonio with the winners advancing to the national title game two days later.
