NCAA Basketball Picks: Take Illinois ATS vs Missouri
The No. 13 Illinois Fighting Illini will look to continue their hot start to the season when they clash with the Missouri Tigers on Friday. The Illini have already picked up a conference win this season and will try to bounce back from just their second loss of the season. Missouri will hope to turn things around near its home base amid a losing skid, but NCAA basketball odds favor Illinois in the matchup.

Illinois vs Missouri Game Information
- Game: Illinois (8-2) vs Missouri (7-4)
- Location: Enterprise Center, St. Louis, MO
- Day/Time: Friday, Dec. 22, 9 p.m. ET
- Illinois vs Missouri Live Stream: TBS.com
The Missouri Tigers will hope to end a two-game losing streak when they battle the Illinois Fighting Illinois on Friday, Dec. 22 at the Enterprise Center. NCAA basketball lines favor the Illini by 6 ½ points, with BetUS Sportsbook setting the total at 149½ points.
Illinois vs Missouri Odds and Spreads
Illinois vs Missouri Betting Trends
- The Fighting Illini are 5-0-1 ATS in their last 6 games overall.
- The Fighting Illini are 4-0-1 ATS in their last 5 games following a straight up win.
- The Fighting Illini are 3-0-1 ATS in their last 4 games following a ATS win.
- Illinois has compiled a 6-5-0 record against the spread this season.
- Missouri has compiled a 3-8-0 record against the spread this year.
- Tigers are 0-7 ATS in their last 7 games as a favorite of 13.0 or greater.
- Tigers are 0-6 ATS in their last 6 neutral site games as a favorite.
- The Fighting Illini are 0-5 ATS in their last 5 neutral site games as a favorite.
ATS Pick: Illinois -6½
Though the Missouri Tigers are likely to get a strong following in St. Louis, Illinois should get another strong win in the neutral-site matchup. The Fighting Illini have been strong this season, and despite a recent loss to Tennessee, they have shown little signs of slowing down.
Illinois has averaged 82.2 points on 46.6% shooting in its last five games, and it should be poised for another strong game offensively against a Missouri defense that has had trouble stopping teams lately. In their last two losses, the Tigers allowed 83 points a game to Seton Hall and Kansas, and they’ll get another tough offense in Illinois.
With the Fighting Illini’s defense also playing well, Missouri is likely to have trouble keeping up, and Illinois should be a solid NCAA betting pick to cover the spread.
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