Ole Miss vs Iowa State Odds, Prediction and March Madness Picks March 23

Even without injured guard Keshon Gilbert, third-seeded Iowa State had no trouble with Lipscomb in its March Madness opener on Friday. The degree of difficulty figures to increase with a matchup against an Ole Miss squad that just held North Carolina to 21% shooting on 3-pointers in its first-round win.

The teams have met just once in the last 24 years, with Iowa State winning 87-73 in 2019. Expect a closer contest this time around when making your March Madness bets.

Iowa State is listed by the college basketball lines as the five-point favorite with -220 odds to win outright. Ole Miss is coming off its first NCAA tournament win since 2015 and has +185 odds to advance to the Sweet 16 with a win.

Ole Miss vs Iowa State Prediction Today March 23

My prediction

Iowa State 76, Ole Miss 73

When making March Madness predictions, remember that Iowa State is 17-12 against the college basketball spreads as a favorite this season. Ole Miss counters with a 9-6 ATS mark as the underdog.

One Down.#Cyclones | #C5C | @cade_for3 pic.twitter.com/IC7QNnGeIl

— Iowa State Men’s Basketball (@CycloneMBB) March 21, 2025

Ole Miss comes into this game with a 4-2 mark in March, with the two losses coming against teams with high NCAA championship basketball odds (No. 1 seeds Auburn and Florida). The Rebels led North Carolina by as many as 22 points in their March Madness opener. Iowa State shot 68% inside the 3-point line to advance to the second round with ease.

This could be decided in the final few possessions and one of the NCAAB expert picks to consider is for Ole Miss to cover as the five-point underdog.

Top 3 Ole Miss vs Iowa State Betting Picks

My top picks

1. Ole Miss vs Iowa State ATS Pick: Ole Miss +5
2. Ole Miss vs Iowa State O/U Pick: Over 146
3. Ole Miss vs Iowa State top prop: F Joshua Jefferson Over 7.5 Rebounds

My Analysis

Per the Ole Miss vs Iowa State betting trends, the Rebels have lost seven of their last nine games when listed as the underdog heading into the matchup with Iowa State

Iowa State made NCAA basketball news as it was ranked as high as No. 2 in the national polls and didn’t fall out of the top 10 until earlier this month after losing in double overtime to BYU. Milan Momcilovic, a 6-8 sophomore, missed some time in January and February, but he looked pretty healthy in the tournament opener with 20 points and five rebounds.

Take Iowa State to survive and advance, with forward Joshua Jefferson (7.4 rebounds per game) anchoring the interior, but Ole Miss will make the Cyclones work for this victory.

Ole Miss vs Iowa State March Madness Best Prop Bet

Curtis Jones Over 16.5 Points (-124)

After nailing seven 3-pointers in a loss to BYU in the Big 12 tournament, Curtis Jones was a little quieter with one 3-pointer and 17 points in 27 minutes against Lipscomb in the first round.

Curtis Jones is not only playing at an All-American level, but he is one of the humblest & most likable players you will find.

He showed me around Iowa State & we talked about everything – his journey from JUCO, coach TJ’s program culture, team success/aspirations + more!🌪️ pic.twitter.com/L0rJWxzGyd

— Ryan Hammer🔨 (@ryanhammer09) January 19, 2025

We like him to have a much better game in this one, making his scoring prop over going over 16.5 points one of the top NCAAB experts picks.

Bet On Curtis Jones Over 16.5 Points (-124)

Ole Miss vs Iowa State How To Watch

• Game: Ole Miss (23-11) vs Iowa State (25-9)
• Date/Time: Sunday, March 23, 7:45 p.m. ET
• Location: Fiserv Forum, Milwaukee, WI
• Ole Miss vs Iowa State Live Stream: Fubo.tv