Oregon vs Arizona Odds, Prediction and March Madness Picks March 23

A pair of familiar foes will square off in the second round of the South Region when former Pac-12 Conference members Arizona and Oregon battle for a spot in the Sweet 16. The Wildcats enter as 3.5-point favorites in this second-round showdown, with the total set at 152.5.

Both teams dominated their first-round games and come in hot, but Oregon’s recent run has bettors and NCAA basketball odds experts wondering if another March stunner is brewing. While neither team is precisely a favorite to win NCAAB Championship, that doesn’t mean this round of 32 game will lack any excitement or betting value.

Oregon vs Arizona Prediction Today March 23

My prediction

I’m rolling with the Ducks to make this one messy for Arizona. Oregon coach Dana Altman has a March track record you can trust, and his team has been trending up for over a month. Since Feb. 11, the Ducks have won nine of 10 and are playing like a top-15 team in the country.

Arizona’s offense is lethal, but it relies heavily on rhythm, and Oregon’s shifting defensive looks can take teams out of their comfort zone. I still think Arizona has the better top-end talent, but Oregon has the better coach, the hotter team, and the confidence to get this done. I’m confident in adding Oregon to my college basketball picks to end the weekend.

Top 2 Oregon vs Arizona Betting Picks

My top picks

1. Oregon vs Arizona ATS Pick: Oregon +3.5
2. Oregon vs Arizona O/U Pick: Over 153

My Analysis

Oregon +3.5 is the sharp side with Arizona’s neutral-court inconsistency and coach Tommy Lloyd’s shaky March track record. The Ducks are rolling defensively and have the coaching edge with Altman. Looking at the Oregon vs Arizona stats, both teams rank top 50 in tempo and combine for 158.5 points per game, so the over 153 offers strong value, especially after a slight dip.

With momentum, depth, and a proven March blueprint, Oregon is built to make this a fight and make some college basketball news with the upset.

Arizona vs Oregon in Seattle

It’s like we never left each other pic.twitter.com/yFGq55W6Nn

— Schrödinger’s Wildcat (@WildcatAgenda) March 22, 2025

Oregon vs Arizona How To Watch

• Game: Oregon (25-9) vs Arizona (23-12)
• Date/Time: Sunday, March 23, 9:40 p.m. ET
• Location: Climate Pledge Arena, Seattle, WA
• Oregon vs Arizona Live Stream: Fubo.tv