Pittsburgh vs Duke Picks: Bet Blue Devils (-14.5) to Cover on January 7
- The Pittsburgh vs Duke betting lines favor the Blue Devils by 14.5 points.
- The Pittsburgh vs Duke game to go over 143.
- Check out our picks and make your bets at BetUS Sportsbook.



Two of the three teams still perfect in ACC play will be squaring off in a nationally televised game in front of the Cameron Crazies. The sports betting odds have host Duke as a double-digit favorite.
Pittsburgh hadn’t won at Duke since 2007 before last year’s 80-76 win with the game landing over the total. The Blue Devils had won nine of the previous 10 games. Pittsburgh did cover in five of those contests.
The college basketball lines have Duke as a 14.5-point favorite against Pittsburgh. Duke is priced at -1300 to win outright compared to +780 odds for the Panthers to stay undefeated in the ACC.
When looking at the college basketball futures odds, Duke is second at +750 behind only Auburn in the odds of winning the national championship. Pittsburgh’s championship odds have moved from +12500 to +7500 since the start of the season.
Pittsburgh vs Duke Game Information
- Game: Pittsburgh (12-2, 3-0 ACC) vs Duke (12-2, 4-0)
- Date/Time: Tuesday, Jan. 7, 7 p.m. ET
- Location: Cameron Indoor Stadium, Durham, NC
- Pittsburgh vs Duke Live Stream: Fubo.tv
3 Pittsburgh vs Duke Best Bets
1. Duke -14.5
One of the biggest upsets in the ACC last season came when the Panthers headed into Cameron Indoor Stadium and stunned the Blue Devils as a 12.5-point underdog. That could spell bad news for Pittsburgh heading into Tuesday’s matchup.
Per NCAAB betting trends, Duke has won eight games in a row with Pittsburgh taking a five-game winning streak into the matchup so ESPN might have a good one. One concern is that the Panthers were not competitive against Mississippi State in the SEC/ACC Men’s Challenge, trailing by as many as 35 points in a 90-57 road loss.
Duke has split its four games against ranked teams with wins over Arizona and Auburn. Pittsburgh’s only game against a ranked squad was an 81-75 loss to Wisconsin at the Greenbrier Tip-Off in White Sulphur Springs, W.Va.
When making college basketball picks, go with the Blue Devils to take command of this game early on.
2. Pittsburgh vs Duke Over 143 (-110)
Duke ranks in the top 10 in both offensive and defensive efficiency according to the Pomeroy basketball database. Pittsburgh is 17th in offensive efficiency but just 42nd on the other end of the court.
Pittsburgh and Duke are third and fourth in the ACC in scoring offense. Even though Duke leads all ACC teams in field-goal percentage defense and in 3-point percentage defense, the 143-point total seems a bit on the low side.
Per the Pittsburgh vs Duke stats, both teams average more than 80 points per game, with this game featuring three of the top eight scorers in the ACC.
Senior guard Damian Dunn hasn’t played since injuring his thumb early in the loss to Wisconsin. He went through some shooting drills before Saturday’s win over Stanford but did not play. Keep an eye on the college basketball injury updates to see if the Panthers’ third-leading scorer will be on the court for this game.
#Pitt guards Ish Leggett and Damian Dunn are warming up ahead of their matchup with Stanford at 6:30
Dunn has missed the last six games after undergoing surgery on his right thumb
Leggett missed the last game vs. Cal with a Lower body injury pic.twitter.com/dae6NNfGMe
— Dominic Campbell (@DOMISMONEY) January 4, 2025
Pittsburgh got leading scorer and rebounder Ishmael Leggett back after he missed the Cal game.
When looking at the Pittsburgh vs Duke best bets, go with the game to land over 143.
Bet On Pittsburgh vs Duke Over 143 (-110)
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3. Duke’s Cooper Flagg Top Prop Pick Option
It looked like Duke star Cooper Flagg hit the freshman wall when he was held under 50% shooting in six consecutive games. However, in the last two games, he is 16 of 26 from the field (4 of 6 on 3-pointers) and has made all 12 of his free throws. He is coming off his fourth game with at least 20 points and 10 rebounds.
5 players have swept ACC POW/ROW 2x in a season.
All 5 are Duke Blue Devils. pic.twitter.com/aOyQ4dR8gy
— Duke Men’s Basketball (@DukeMBB) January 6, 2025
Flagg could be a tempting player prop option in both points and rebounds. He also averaged 4.5 assists in wins over Virginia Tech and SMU. His over/under is 19.5 points
For Pittsburgh, Jaland Lowe has 36 assists over his last four games.
Bet On Pittsburgh vs Duke player props
Pittsburgh vs Duke Prediction
Duke 87, Pittsburgh 72
Questions Of The Day
Which team has a better record against the spread this season, Pittsburgh or Duke?
Duke and Pittsburgh are tied with Florida State with an ACC-best 9-5 mark against the college basketball spread.
When was the last time a Pittsburgh game at Duke landed under the total?
The last four times Pittsburgh was on the road against Duke, the game landed over the total. The last game in Durham between the team to land under was in 2018 when the Blue Devils won 81-54.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets