Virginia vs Louisville Prediction, Game Preview, Live Stream, Odds and Picks
Louisville Tries to Stop Skid
Virginia Hopes to Remain on Top
Two Atlantic Coast teams will meet for the first time this season when the Virginia Cavaliers visit the Louisville Cardinals on Wednesday night.
The Cavaliers will be looking for their third straight win after their recent loss to rival Virginia Tech ended a seven-game win streak. Virginia is behind Pittsburgh atop the ACC with an 11-3 conference record.

The Cardinals are on the opposite end of the conference. Louisville is riding a three-game losing streak and its one win in conference play has placed it last in the ACC.
According to college basketball odds, Virginia (+2500) is tied for the 11th-best odds to win the national title. The Cavaliers (-160) also have the best odds to win the ACC.
Let’s check the latest college basketball news, stats, injury reports, and college basketball lines for Virginia vs Louisville. We’ve got plenty of NCAA basketball picks for you to consider.
Virginia Overcomes Overtime
The defense has led the way for the Cavaliers all season, and Saturday’s overtime win was no different.
Virginia leads the ACC in points allowed and is third in field-goal percentage allowed, with teams averaging 60.4 points on 41.4% shooting. In the Cavaliers’ last two wins, their opponents averaged 56 points on 39.1% shooting.
Aside from its rebounding, where Virginia was outrebounded 39-24 and gave up 16 second-chance points, Virginia’s defense pulled through in its 69-62 win once again.
The Cavaliers forced 22 turnovers, leading to 20 points, while also holding Duke’s leading scorer, Kyle Filipowski, scoreless.
Virginia’s strong defense will continue to be key to its success as it closes out the season.
Louisville Shows Improvement
The Cardinals won their first conference game a couple of weeks ago, and their offense has continued to show improvement in the last few games.
Louisville is last in the ACC in points and second-worst in shooting percentage, averaging 64 points on 41.7% shooting, but it has gotten better in both areas recently. In three of the Cardinals’ last four games, they averaged 77 points on 50.1% shooting.
The Cardinals’ leading scorer, El Ellis, averages 17.4 points a game and has been big in games when the offense has been strong. In those three recent games, Ellis averaged 22 points a game.
Though Louisville’s offense has gotten better, its last-place defense remains an issue, as opponents have averaged 88.3 points a game in its last three games.
The Cardinals’ improved offense will be important to secure a second conference win, but their defense will have to show improvement as well.
Virginia vs Louisville Game Injuries
Virginia vs Louisville Head-to-Head
Wednesday’s meeting will be the first of two Virginia and Louisville have this season. The two have played each other 25 times and Virginia has owned the series to this point, leading 20-5.
The Cavaliers have won 14 of the last 15, including the last matchup, a tight neutral-site game in New York that Virginia won 51-50 in March 2022.
Virginia vs Louisville Game Information
- Game: No. 7 Virginia (19-4, 11-3 ACC) vs Louisville (3-22, 1-13)
- Location: KFC Yum! Center, Louisville, KY
- Day/Time: Wednesday, Feb. 15, 7:00 p.m. ET
- Virginia vs Louisville Live stream: TBS.com
Virginia vs Louisville Betting Lines
Virginia vs Louisville Picks and Prediction
Wednesday’s game may be pretty one-sided with Virginia’s success and the struggles Louisville has shown this season.
The Cardinals are showing offensive improvement, but the Cavs have one of the best defenses in the league and shouldn’t make things easy. Though Virginia’s offense is mediocre, it should be able to score against a Louisville defense that is last in the ACC, allowing 76.1 points a game. Virginia should be able to pick up another win on the road.
The Virginia Cavaliers are listed at -1745 in our Vegas college basketball lines. This means that if you wager $100 on the Cavaliers, you have a chance to win $6. The Louisville Cardinals are +955, offering a chance to win $955 on a $100 wager.
The implied probability attached to the betting lines gives the Virginia Cavaliers a 94.58% chance to win, with the Louisville Cardinals at 9.48%.