Big 12 Week 1 Best Bets: West Virginia, TCU and Colorado
- The Big 12 welcomes Utah, Arizona State, Arizona, and Colorado to the conference.
- West Virginia could boost the perception of Big 12 with an upset over Penn State.
- Let’s explore the top bets in the Big 12 for Week 1.
- Check the latest NCAA football odds at BetUS!
It is hard to imagine a more fun conference than the wide-open Big 12 which makes the NCAA football odds challenging to predict. Before conference play begins, the Big 12 begins the season with non-conference matchups.

“The Big 12 is the deepest conference in the country.” The @Big12Conference matchups are going to be WILD this season 🔥 @joelklatt and @JoshPateCFB share that the conference might only get one team in the CFP but the games will be a BATTLE 😤 pic.twitter.com/8ScpKH3PE2
— The Joel Klatt Show: A CFB Pod (@JoelKlattShow) August 26, 2024
The majority of Big 12 teams will be heavy favorites versus perceived inferior opponents, including several FCS programs. Like the ACC and Big Ten, this is a new-look Big 12 conference with Texas and Oklahoma now in the SEC.
The Big 12 welcomes Utah, Colorado, Arizona, and Arizona State this season.
Let’s dive into the best Big 12 bets for Week 1.
Make These 3 Big 12 Bets in Week 1
1. Colorado Cruises Despite Public Backing North Dakota State
This has been the summer to fade Colorado after the Buffs were the media darlings during the first month of last season. Casuals are seeing this matchup and immediately identify North Dakota State as being a perennial FCS powerhouse.
Yet, this is not your granddaddy’s North Dakota State. The Bison lost head coach Matt Entz along with several key players over the offseason.
We’ve seen this number closer to NDSU, but Colorado is not up to a 10-point favorite over North Dakota State. You could see some value by waiting until closer to kickoff for the NCAA football line to drop if you’re backing Colorado.
“I’m all for Coach Prime, man. He’s doing a great job at Colorado… I think they’ll take the next step in terms of a team this year.”
– Nick Saban pic.twitter.com/mCZDLjxHAg
— RK (@RyanKoenigsberg) August 24, 2024
Touchdown Profits! Bet $200, Get $450 Bonus on first time deposit.
Coach Prime and Shedeur Sanders get to open the season with some home cooking at Folsom Field. Colorado should win this one comfortably as a tune-up for Big 12 play. Bet online on Colorado to cover the spread.
Bet on Colorado -10 vs North Dakota State
2. West Virginia Should Have Penn State on Upset Alert
I keep pumping up West Virginia, so the joke could be on me if the Mountaineers lay an egg versus Penn State. Yet, there is reason for optimism this season for WVU.
Pat McAfee says he can’t wait to get to Morgantown and that #WVU has what it takes to beat James Franklin and Penn State! pic.twitter.com/gZ0L5F8K2D
— The Voice of Morgantown (@voicemorgantown) August 26, 2024
West Virginia is a sizable 8½-point home dog versus Penn State in the NCAA odds. The Mountaineers offense shined, scoring 30 or more points in seven of their final eight games. Garrett Greene looks like a legitimate QB1 for West Virginia.
The Mountaineers get this opening matchup at home, and I like West Virginia to cover the spread versus Penn State.
Bet on West Virginia +8½ vs Penn State
3. TCU Has a Chance to Bounce Back in 2024
We all saw TCU’s letdown last season after making the national title game in the 2022 season. Expect the Horned Frogs to be improved this season.
TCU opens the season as a 9-point favorite versus Stanford. The Cardinal are in for a rude awakening as the program transitions to the ACC.
#BeatStanford pic.twitter.com/B33jVNjgpM
— TCU Scouting (@TcuScouting) August 26, 2024
The Horned Frogs have plenty of weapons for quarterback Josh Hoover to keep TCU competitive this season. Take TCU to cover the spread versus Stanford at the BetUS sportsbook.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
Questions of the Day
Who are the new teams in the Big 12?
Colorado, Arizona, Arizona State and Utah are all in the Big 12 this season.
What is a good Big 12 bet for Week 1?
Take Colorado to cover the spread versus North Dakota State in Week 1.