CFP Prediction: Tennessee vs Ohio State Spread, Over/Under and Prop Picks for Dec 21

Ohio State and Tennessee haven’t played since 1995 so there aren’t many college football betting trends to lean on in what could be a compelling CFP matchup.

The Buckeyes are favored by 7 points according to BetUS Sportsbook. Ohio State is priced at -281 to win outright with Tennessee at +236 to pull off the upset.

A devastating turn of events for Ohio State, as starting center Seth McLaughlin is reportedly out with a torn Achilles 💔🙏@joelklatt reacts to how the loss of a “foundational piece of that offensive line” impacts a game with massive implications in the Big Ten. ⬇️ pic.twitter.com/ozHMtqphcI

— The Joel Klatt Show: A CFB Pod (@JoelKlattShow) November 20, 2024

Let’s take a look at my top 3 college football picks today for this game.

Tennessee vs Ohio State Game Information

• Game: Tennessee (10-2) vs Ohio State (10-2)
• Date and Time: Saturday, Dec. 21, 8 p.m. ET
• Location: Ohio Stadium, Columbus, OH
• Tennessee vs Ohio State Live Stream: Fubo TV

Get the latest Tennessee vs Ohio State stats here.

Tennessee vs Ohio State Picks: Best ATS, Over/Under and Prop Bets

1. Tennessee ATS +7

It might be hard to find a team in the College Football Playoff field with a more talented quarterback-running back tandem than Tennessee.

Tennessee redshirt freshman Nico Iamaleava is a rising star who has completed at least 69% of his passes in his last two games while Dylan Sampson has topped 100 yards in all but two games this season.

If any player can single-handedly stop Ohio State’s CFB Playoff run dead in its tracks, it is Tennessee RB Dylan Sampson.

Here is what makes Sampson great and how the Vols get him the ball 🧵 pic.twitter.com/aO4wuqFysY

— Cole Topham (@crtopham_) December 17, 2024

Meanwhile, the Buckeyes lost at home to a mediocre Michigan team. That kept the Buckeyes out of the Big Ten title game and bumped them down to the No. 8 seed in the CFP.

It could be argued that Tennessee is more deserving of a home game than Ohio State. However, that is not how it played out. This could be the most competitive of the first-round games and when making college football picks, we’ll take Tennessee to cover as a 7-point underdog.

Bet This Pick: Tennessee +7 (Ev)

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2. Tennessee vs Ohio State Over 46

With Ohio State ranking first and Tennessee coming in at No. 4 in the country in total defense, this is the first-round College Football Playoff with the lowest total set by our college football betting odds.

Converting in the red zone is not easy against either of these teams with Ohio State allowing just 16 scores and 10 touchdowns in 29 red-zone drives by the opposing team. Tennessee has surrendered just 15 TDs on 34 red-zone possessions.

However, these teams have had some time to get ready since neither the Buckeyes nor the Volunteers played in their conference title games. That is enough to go with this game to land over the total.

Bet This Pick: Tennessee vs Ohio State Over 46

3. Best Game Prop: Neither Team to Score Three Times in a Row (+197)

There are performances when Tennessee and Ohio State look like title contenders and then times when the Volunteers and Buckeyes are hard to trust.

When making college football predictions, this could be a back-and-forth affair between teams with plenty of future NFL players on the roster.

One of the most enticing NCAA football props today is to have neither team score at least three times in a row.

Bet This Pick: Neither Tennessee nor Ohio State to Score Three Times in a Row (+197)

Tennessee vs Ohio State Score Prediction

Ohio State 30, Tennessee 24

Questions of the Day

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.