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Florida State vs Louisville Prediction, Game Preview, Live Stream, Odds and Picks

Early Showdown Between ACC Rivals

Seminoles Look to Stay Perfect

Making college football picks is no longer reserved for Saturday as there always seems to be at least one big matchup on Friday night. That’s the case in Week 2 as the Louisville Cardinals are set to play host to the Florida State Seminoles for an ACC matchup.

Florida State comes into this game with a perfect 2-0 record, and that includes a road win against the LSU Tigers. The Seminoles are trying to prove that they are back as a college football power, but they can’t slip up in this one.

Florida State vs Louisville Prediction, Game Preview, Live Stream, Odds & Picks
ANDY LYONS / GETTY IMAGES NORTH AMERICA / Getty Images via AFP

Louisville has had an interesting start to this season but comes into this game with a ton of momentum. The Cardinals went on the road to knock off a very good UCF team last weekend to set up a huge battle in this one.

The college football odds for this matchup have the Florida State Seminoles as 2½-point favorites over the Louisville Cardinals.

Let’s check the latest NCAA odds, stats, injury reports, and college football lines for Florida State vs Louisville.

Seminoles Running Over Opponents

It’s been a long layoff for Florida State after beating LSU on Sept. 4, but this team has a clear plan of attack. Florida State is averaging 269 rushing yards and will be looking to run the ball against Louisville.

Quarterback Jordan Travis has helped out in the run game, but he has also thrown for 467 yards and a pair of touchdowns. Travis has shown that he has the ability to make clutch plays late in games, and Florida State will give him that opportunity.

Florida State is holding opponents to just 15 points per game and the defense could play a key role in this one. If the Seminoles can continue to stop the run, they will be hard to beat.

Louisville Looking for Some Scoring

Louisville has been scoring a ton of points in recent years but won its most recent game with defense. Head coach Scott Satterfield was proud of his team in beating UCF, saying, “It was tough, it was hard-fought and our defense played outstanding.”

The Cardinals have been defense, but they have also allowed 208 rushing yards per game. Louisville is going to have to stop the run to keep the Seminoles honest.

Quarterback Malik Cunningham made clutch plays in Week 2, but that wasn’t the case in the season opener – a 31-7 drubbing at Syracuse.

Florida State vs Louisville Head-to-Head

Florida State and Louisville are newer rivals when it comes to college football, as they have met up just 22 total times. Looking at the scores and odds from previous matchups in this rivalry can help make picks in this game.

The Seminoles are 16-6 all-time against the Cardinals, but Louisville won the last two games.

Florida State vs Louisville Game Information

  • Game: Florida State (2-0) vs Louisville (1-1)
  • Location: Cardinal Stadium, Louisville, Ky
  • Day/Time: Friday, Sept. 16, 7:30 p.m. ET
  • Florida State vs Louisville Live Stream: ESPN

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Florida State vs Louisville Betting Lines

Florida State vs Louisville Prediction

Both of these teams are looking for a big conference win to propel their seasons, and this one should be tightly contested. Home-field advantage tends to matter in the ACC matchups, and Louisville has won two straight games over Florida State.

In the end, though, it’s going to be the offense of Florida State that creates the separation in this game. Louisville just hasn’t been good enough offensively, and quarterback Travis will have another big game for the Seminoles.

Head to BetUS Sportsbook and take the Florida State Seminoles -2½ as they go on the road and knock off the Louisville Cardinals.


The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

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