Indiana vs Notre Dame Prediction, Odds and NCAAF Picks: Bet Hoosiers +7 on December 20

Indiana and Notre Dame will meet for the 30th time, but the Hoosiers have not won since 1960. The question you must ask yourself before making your online bet is whether Indiana is poised enough to get off to a strong start in enemy territory.

Read on to find the best college football picks this week for the game.

Indiana vs Notre Dame Game Information

• Game: Indiana Hoosiers (11-1) vs Notre Dame Fighting Irish (11-1)
• Location: Notre Dame Stadium, Notre Dame,,Ind.
• Day/Time: Friday, December 20, 8:00 p.m. ET
• Indiana vs Notre Dame Live Stream: FuboTV

Get updated Indiana vs Notre Dame injuries here.

Indiana vs Notre Dame Betting Trends

• Notre Dame has won the last six meetings and is 23-5-1 in the series.
• The over is 8-0 in Indiana’s last eight games as a road underdog.
• The Irish are 6-0 ATS versus the last six Big Ten foes.
• The Hoosiers have covered the spread in nine of the last 11 contests.
• Notre Dame has hit the first-quarter moneyline in its past five home games.

3 Bets for Indiana vs Notre Dame: ML, ATS and Over/Under Picks

1. Indiana ATS +7

Kurtis Rourke finished ninth in the voting for the Heisman Trophy after throwing for 2,827 yards in 11 games with 27 touchdown passes and just four interceptions.

Rourke struggled against Ohio State (8-of-18, 68 yards), was sacked five times and still had the Hoosiers tied until the final seconds of the first half. The 6-5 signal caller is in his sixth season of college football and can learn from that experience.

Marcus Freeman on Kurtis Rourke: “He’s a veteran. He’s been in big games. He’s played a lot of football games and he makes really good decisions. He knows what he’s looking for.” #iufb

— Zach Osterman (@ZachOsterman) December 15, 2024

Indiana will face a similar defense in Notre Dame, which has 30 sacks and 17 interceptions (tied for fourth in the nation). Much of your college football betting odds will depend on getting yards on first down and giving Rourke time to find receivers.

We think the Hoosiers can keep the ball with running backs Justice Ellison (811 yards, 10 TDs) and Ty Son Lawton (634, 12). Rourke also has four receivers with 400 yards, led by Elijah Sarratt (49 catches, 890 yards, eight TDs).

Bet Indiana +7 (-106)

2. Notre Dame ML (-280)

Perhaps the biggest key to the game, other than Indiana’s ability to grasp the big moment, is what happens in the trenches.

Notre Dame is 10th in the nation in rushing yards per game (224.8) and would like to control the game without forcing quarterback Riley Leonard to throw. The good news for the Irish is that top rusher Jeremiyah Love (949 yards, 15 rushing TDs) has been deemed fit to play.

Backup Jadarian Price (651 yards, 7.3 per carry, 7 TDs) has been good, but with Love Notre Dame has three big weapons in the backfield with Leonard (721 yards, 14 TDs rushing). In addition, defensive lineman Howard Cross III appears ready to go.

JEREMIYAH LOVE GOT WAY UP ON THIS HURDLE! pic.twitter.com/ndP0p0hFlL

— CBS Sports (@CBSSports) November 30, 2024

The rushing attack is why the Irish are the right bet to edge past the Hoosiers.

Bet Notre Dame’s moneyline and use it as a college football parlay pick to provide more value.

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3. Indiana vs Notre Dame Under 50.5

Indiana is second and Notre Dame third in the nation in scoring. They average 83.1 points per game between them. So why bet on the under in this matchup?

For one thing, both defenses are pretty good, too.

Xavier Watts has five interceptions for Notre Dame (tied for third in the country) and the Irish allow 13.6 points per game. Indiana is second in the nation in yards per game against (244.8) and Mikail Kamara boasts 10 sacks.

XAVIER WATTS SENDS THE IRISH TO THE PLAYOFFS
pic.twitter.com/QSCLnRCFHB

— Sidelines – Notre Dame ☘️ (@SSN_NotreDame) December 1, 2024

The other reason is how big the moment will be for both teams. Sometimes games like this become a shootout, but more times than not the teams get conservative and the defenses are more focused. That is the college football prediction for this matchup.

Bet on Indiana vs Notre Dame 50.5 (-106)

Need More Knowledge? Take a Look at These Other CFB Betting Articles

• CFP Predictions: Why Notre Dame Could Win National Title
• CFP Predictions: Why Indiana Could Win National Title

Questions Of The Day

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets