The No. 10 Clemson Tigers are in bounce-back mode as they look to get back in the win column against the Louisville Cardinals. In epic fashion, the Tigers were annihilated by an unranked Notre Dame team on Saturday. Meanwhile, Louisville beat down James Madison to become bowl eligible with a fourth straight win.
Let’s check the latest college football odds, stats, injury reports, and college football lines for Louisville vs Clemson. We’ve plenty of NCAA football odds for you to consider.
Louisville Coming off Big Win
The Cardinals are playing some surprisingly good football this season, and it won’t be a walk in the park for Clemson. The Cards are on a four-game winning streak and just qualified for a bowl. Additionally, they already beat a No. 10 team this season in Wake Forest.
Louisville has a very run-heavy offense that could struggle on Saturday with Clemson’s 18th-ranked rushing defense. Clemson allows a ton of passing yards, but its rushing defense has been enough to keep them afloat. This is not great news for Louisville or its running game. QB Malik Cunningham leads the team in rushing with 541 yards while the three running backs all have over 275 yards on the season.
But, facing off against an angry Clemson defense, we are not full of confidence in Louisville’s ability to make much noise.
The Clemson Tigers responded to landing at No. 4 in the CFP rankings by going right out and losing to an unranked team. Not only losing, but losing badly. The Fighting Irish shut down Clemson’s offense and allowed QB D.J. Uiagalelei had just 191 yards passing with one touchdown and one interception. Clemson clinched the ACC Atlantic Division despite the loss, but their goal was always a shot at the national championship.
With one loss, they will be hard-pressed to fight back into the final four teams. A statement win over Louisville will go a long way to convincing voters. But, with a spread of just seven points, bookmakers aren’t that confident in their ability to snap back.
Louisville vs Clemson Injury Report
Louisville vs Clemson Head-to-Head
The Cardinals and Tigers have played seven times since 2014, with Clemson winning all seven. Louisville is 2-5 against the spread.
Louisville vs Clemson Game Information
- Game: Louisville vs Clemson
- Location: Memorial Stadium, Clemson, SC
- Day/Time: Saturday, Nov. 11, 3:30 p.m. ET
- Louisville vs Clemson Live Stream: ESPN
Louisville vs Clemson Betting Lines
Louisville vs Clemson Picks & Prediction
What’s more dangerous than a cat backed into a corner? A Tiger, of course. And that is how we view Clemson right now. They clinched the division and will be heading to the ACC title game. But they want a crack at the CFP and won’t allow Louisville to stand in their way. We expect a big day from Clemson on both sides of the field.
The Clemson Tigers are listed at -280 in our Vegas NCAAF lines. This means that if you wager $100 on Clemson, you have a chance to win $36. The Louisville Cardinals are +230, offering a chance to win $230on a $100 wager.
The implied probability attached to the betting lines gives Clemson a 73.68% chance to win, with Louisville at 30.30%.