Nebraska vs USC Picks: Bet Cornhuskers for Outright Upset 11/16
- The Nebraska vs USC betting line is -9 for the Big Ten matchup.
- Nebraska is a +272 moneyline underdog to pull off the road upset.
- Get the best Week 12 odds at the BetUS Sportsbook.

There could be an upset brewing when the Nebraska Cornhuskers face the USC Trojans on Saturday at Los Angeles Memorial Coliseum.
Bettors get Nebraska at +272 to win outright and +9 with college football odds, and it’s good enough to hand the Trojans their fifth loss in their last six games.
The Cornhuskers look to end a three-game skid, but with desperation seeping in, we expect a close contest at Los Angeles Memorial Coliseum.
Nebraska vs USC Game Information
- Game: Nebraska Cornhuskers (5-4, 2-4 Big Ten) at USC Trojans (4-5, 2-5)
- Date/Time: Saturday, Nov. 16, 4:00 p.m. ET
- Location: Los Angeles Memorial Coliseum, Los Angeles
- Nebraska vs USC Live Stream: FOX
Before placing any bets on the game, monitor all the college football news for injury updates.
2 Keys to Bet on Nebraska vs USC
1. Underdog Cornhuskers Primed for Upset
It has been a case of close but no cigar for the Cornhuskers, who lost to Ohio State 21-17 before losing to UCLA 27-20 two weeks ago.
They have a bye week under their belt, but their loss to No. 2 Ohio State is an excellent form guide. They almost defeated one of the best teams in college football and it came on the road.
“Give Nebraska credit and the job they did,” Ohio State coach Ryan Day said. “They had a hard time the week before. We knew they were going to come out and play us really hard.”
If they play anywhere near that level on Saturday, the Cornhuskers will blow the Trojans out of the water. However, as the NCAAF spread suggests, a repeat of that game might not be on the horizon for the visitors.
If Nebraska can limit turnovers, it is good enough to win and at least cover the +9 spread. We priced the Cornhuskers at +6½, so bettors get a few more points to work with than we expected.
Money could come for the Cornhuskers, so expect to see the line firm before game day. Lock in Nebraska now when betting online.
Touchdown Profits! Bet $200, Get $450 Bonus on first time deposit.
2. Is USC Wrongly Favored?
We expected USC to be favorites at home, but the Trojans could be false favorites at the -9 mark, and our NCAAF expert betting picks aren’t including it this week.
The Trojans are 4-5 following a 26-21 loss to Washington on the road, which followed a good 42-20 win over Rutgers. However, prior to that win, they lost three consecutive games to Minnesota, Penn State and Maryland.
We’ll five them credit for pushing Penn State to overtime. The Nittany Lions are one of the highest-ranked teams in the country, so credit where credit is due. However, we didn’t see enough from them against Washington to take a -9 line.
One factor in Nebraska vs USC betting trends is the offensive disparity. USC is averaging about 10 more points than the Cornhuskers in Big Ten play.
USC QB Miller Moss has been only fair in taking over from Caleb Williams. He has 18 touchdowns and nine interceptions, but we have been more impressed with running back Woody Marks, who is quickly approaching 1,000 rushing yards.
I can’t believe more #NFLDraft scouts aren’t discussing USC’s Woody Marks as one of the best running backs in this 2025 class.
His rushing + receiving ability is tailor-made for today’s NFL. He’s been dominating for the Trojans this fall. 251 career receptions and counting. pic.twitter.com/SOckZsaOto
— Ray G (@RayGQue) November 5, 2024
If Marks makes his mark on the game, USC could cover the spread. However, we expect this Big Ten rivalry game to be decided in the final quarter.
How to Bet on Nebraska vs USC
We’re taking Nebraska ML and +9 for a bit of value. The Cornhuskers are good enough to score an upset at +272, which is a generous enough line to include them in our college football predictions.
Naturally, we’re also including +9 in our NCAAF parlays. We think the game will be decided by under a touchdown and the game could head into overtime.
It’s also worth including under 50½ points in college football best bets. It could be a tight defensive battle, where both quarterbacks make errors in the red zone. That should play right into the hands of under backers.
Questions of the Day
What are the odds for Nebraska vs USC game?
The USC Trojans are -9 favorites against the Nebraska Cornhuskers on Saturday.
Who won the most recent meeting between Nebraska vs USC?
USC won 45-42 in 2014, and they are 4-0-1 overall against the Cornhuskers.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.