Pittsburgh vs Louisville Picks: Double Up on Cardinals in Parlay Bet on 11/23

The Louisville Cardinals have not been a good bet lately and hope to change that trend as an 8½-point favorite in the college football odds on Saturday when they host the Pittsburgh Panthers for an ACC matchup.

Louisville has lost four of seven games since a promising 3-0 start and is even worse in that stretch for backers (1-6 ATS). The Cardinals followed up an upset win at Clemson on Nov. 2 by blowing a two-touchdown lead last week at Stanford in a 38-35 setback.

Pittsburgh has dropped three in a row after a 7-0 start, including the last two in demoralizing fashion. The Panthers were upset by Virginia 24-19 two weeks ago before coughing up a late lead in a 24-20 defeat against Clemson.

Before making your online bet, you must choose which team might be in the best mindset for this late-season contest. Or, you just go with the home team.

Pittsburgh vs Louisville Game Information

• Game: Pittsburgh Panthers (7-3, 3-3 ACC) vs Louisville (6-4, 4-3)
• Location: L&N Federal Credit Union Stadium, Louisville, Ky
• Day/Time: Saturday, Nov. 23, 4:00 p.m. ET
• Pittsburgh vs Louisville Live Stream: Fubo.tv

Pittsburgh vs Louisville Betting Trends

• The over is 5-0 in Pittsburgh’s last five games as an underdog of 3.5-10 points.
• Louisville has only covered the first half spread in two of its past 13 outings.
• The Panthers have not hit the first quarter moneyline in any of the last three road games.
• The Cardinals are 0-5 ATS in their last five games following a straight-up loss.
• Pittsburgh has won seven of the last nine meetings, including a 38-21 triumph in 2023.

Top 3 Pittsburgh vs Louisville Betting Tips

1. Why Pick Cardinals to Rebound?

Louisville went ahead 35-21 with 9:44 remaining vs Stanford last week. Cardinals backers were lining up at the pay window, but left with nothing.

Stanford scored on its next two drives, stopped Louisville on fourth down, got the benefit of a bad Cardinals penalty and kicked the winning field goal with no time left.

“We’ve got to have more discipline,” Cardinals coach Jeff Brohm told reporters. “We gave in at the end and did some really dumb things, so we didn’t deserve to win.”

Louisville should come out with resolve after what happened last week and the Cardinals have not stopped scoring points. Quarterback Tyler Shough has thrown for 2,774 yards and 21 touchdowns while Ja’Corey Brooks has 945 receiving yards.

Congratulations to Ja’Corey Brooks @c7_brooks on being named a Biletnikoff Award Semifinalist! The Biletnikoff Award recognizes the college football season’s outstanding FBS receiver at any position @LouisvilleFB @GoCards #OutstandingReceiver #NCFAA pic.twitter.com/byha4DdSQf

— Biletnikoff Award (@biletnikoffawrd) November 19, 2024

Running back Isaac Brown (803 rushing yards) is questionable with a shoulder injury, but Duke Watson is averaging 8.5 yards a carry with five TDs. The Cardinals should be ready to put on a show for the home fans and help people cash NCAA football picks and parlays.

Bet This Parlay Pick: Bet Louisville to win (-310) and -8 ½ (-110)

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2. Why Bet Against Pitt?

Pittsburgh helped cash backers’ college football ATS bets last week despite No. 1 quarterback Eli Holstein (concussion) being out.

The Panthers stymied Clemson through the second half – until the final drive. Tigers quarterback Cade Klubnik ran 55 yards for the winning score. It wasn’t just the loss. It’s the way Pittsburgh lost.

Holstein’s status is still in question. Check late college football news for his status. Backup quarterback Nate Yarnell threw for 350 yards versus Clemson, but he was sacked eight times.

Pitt QB Nate Yarnell on what he’ll take away from this game:

“A lot to learn from. I got to get the ball out faster.”

Says he needs to get the ball to his receivers in space and allowed too many sacks.

— Nathan Breisinger (@NateBreisinger) November 16, 2024

Louisville hasn’t stopped anyone this season and that shouldn’t change Saturday. You just wonder if Pittsburgh can keep up on the scoreboard. The Panthers will need a huge game from Desmond Reid (1,274 yards from scrimmage). Fade Pitt this week.

3. Bet on Plenty of Points in Louisville

Per Pittsburgh vs Louisville stats, these two teams average almost 72 points between them.

The over looks like an easy bet. But the under is just 4-6 in Pittsburgh games and if Brown can’t play for Louisville, that takes away a weapon. It will come down to whether each team’s defensive coaches can get their units to perform.

The Panthers looked good on defense last week and they boast 35 sacks – led by Kyle Louis (7) – along with 12 interceptions. However, Pittsburgh still allows 25 points per game – 0.6 less than Louisville.

Pitt linebacker Kyle Louis’ stat line through 10 games:

83 tackles, 14.5 TFL, 7 sacks, 4 INT

Players nationally with at least 83 tackles, 14.5 TFL, 7 sacks, 4 INT:

Pitt linebacker Kyle Louis

— Chris Peak (@PantherLair) November 20, 2024

The number is set at 57 and we still think they can top it. Yarnell or Holstein must play well, but a 35-24 final looks like a viable college football prediction.

Bet on Pittsburgh vs Louisville Over 57 points (-110).

Need More Knowledge? Take a Look at This Other CFB Betting Article

• NCAAF Picks 3 Ways to Bet on Clemson vs Pittsburgh

Questions Of The Day

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets