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Purdue vs Syracuse Prediction, Game Preview, Live Stream, Odds & Picks

The Syracuse Orange are off to a surprising 2-0 start this season, Head coach Dino Babers entered the hot seat. If he beats Purdue, it will cool down noticeably.

Taking a look at the college football betting odds, the Orange are a slight favorite. The oddsmakers think they can do the job, but what about those who bet online?

Aidan O'Connell #16 of the Purdue Boilermakers passes the ball
Brett Carlsen / Getty Images North America / Getty Images via AFP

Let’s check the latest NCAAF picks, stats, injury reports, and NCAAF odds for Purdue vs Syracuse. We’ve plenty of NCAAF predictions for you to consider.

Purdue Boilermakers

The Purdue Boilermakers rebounded from their Week 1 loss to Penn State, subsequently trouncing Indiana State, 56-0. Quarterback Aidan O’Connell led the way.

He has thrown for 576 yards in two games, while the Boilermaker defense has allowed fewer than 300 yards per game so far.

ISU didn’t offer resistance in what was a cupcake game, but the fact Purdue pitched a shutout should give this defense confidence and belief in its methods.

The loss to Penn State was more about an offensive failure, however, The defense had a late pick-six which should have been sufficient to win, but the offense was unable to protect the lead.

Purdue now encounters another game in which it figures to be tested, and unlike the Penn State game, this one needs to be passed if the Boilermakers are going to be successful this season.

Syracuse Orange

The Syracuse Orange, which looked quite impotent the past few seasons, might be competent. This game against Purdue is more indicative of where the 2022 Orange are standing.

So last week, Syracuse blasted Connecticut, 48-14. Running back Sean Tucker is the featured part of this offense. He’s been given a heavy workload so far this season, as in 48 carries for 212 yards in two games.

Syracuse quarterback Garrett Shrader accounted for five touchdowns against the Huskies (three through the air, two on the ground).

Obviously, a point of caution here is that UConn is a bad team. Purdue’s a much better test here. Syracuse might be for real because of its defense, having surrendered a total of 21 points through two games. It held Louisville-which was expected to have a good offense this season-to just seven points in the opener.

If the Syracuse defense clamps down on Purdue, that will get everyone’s attention, especially those in the sportsbook.

Purdue vs Syracuse Injury Report

Purdue tight end Garrett Miller, defensive tackle Damarjhe Lewis and cornerback Tee Denson are all out for this game.

Syracuse backup quarterback Justin Lamson is out, as are defensive back Dom Foster, fullback Chris Elmore and linebacker Stefon Thompson.

Purdue vs Syracuse Head-to-Head

The teams have met only once, in 2004. Purdue whitewashed SU, 51-0.

Purdue vs Syracuse Game Information

  • Game: Purdue vs Syracuse
  • Location: JMA Wireless Dome, Syracuse, NY
  • Day/Time: Saturday, Sept. 17, 12:00 p.m. ET
  • Purdue vs Syracuse Live Stream: ESPN

Purdue vs Syracuse Betting Lines

Purdue vs Syracuse Prediction

The Purdue loss to Penn State makes this game so much more important to the visitors. It needs to win even more (which isn’t to say the Orange are any less interested).

In a battle of teams who are hard to evaluate at this juncture, give the edge to the Boilermakers on the road. Take them with your college football picks.

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

Purdue vs Syracuse Edge

Purdue vs Syracuse Results

Purdue vs Syracuse Game Injuries

Purdue vs Syracuse Game Summary

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