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Southern California vs Stanford Predictions, Game Preview, Live Stream, Odds & Picks

One of the games that likely brought an end to Clay Helton’s time as USC’s head coach was a 2021 loss to a Stanford team that would win two Pac-12 games a season ago.

It would be quite an understatement to say things are different from the last time USC and Stanford met. USC’s head coach (Lincoln Riley) and quarterback (Caleb Williams) were at Oklahoma last season. Williams is far from the only newcomer as the Trojans had the No. 1 rated class of transfers.

Southern California vs Stanford Predictions, Game Preview, Live Stream, Odds & Picks
Southern California vs Stanford

Only the most loyal of Stanford fans knew much about quarterback Tanner McKee before he threw for two touchdowns in the win over USC in 2021. He also had a touchdown run in the game.

According to the college football lines, Southern California (+150) has the best odds to win the Pac-12 title. Stanford (+8000) is tied for 10th.

The Trojans (+1800) come in fifth in the odds to win the national championship. The Trojans moved up four spots to No. 10 in the Associated Press poll. In the American Football Coaches Association poll, USC went from 15th to 12th.

Let’s check the latest NCAAF picks, stats, injury reports, and NCAAF odds for Southern California vs Stanford. We’ve plenty of NCAAF predictions.

Southern California Trojans

Riley got things off to an impressive start as USC ran for more than 200 yards and averaged 7.4 yards per carry in a season-opening win over Rice.

Williams led the way with 68 yards. According to the college football picks, he has the third-best odds at +550 to win the Heisman Trophy.

Jordan Addison, the 2021 Biletnikoff Award winner as the top receiver in college football, is among the other prominent incoming transfers. He had five catches for 54 yards and a pair of touchdowns in his first game for the Trojans. Williams finished with 249 passing yards and the two TDs to Addison.

Lineman Tyrone Taleni and linebacker Shane Lee each had two tackles for loss in the 66-14 win. Lee also finished with a team-high eight solo tackles.

Stanford Cardinal

E.J. Smith had almost as many receptions as rushing attempts in his first two seasons at Stanford. That all changed in a season-opening win over Colgate as Smith rushed for 118 yards and two touchdowns on 11 carries. He added five catches in the win.

McKee was 22 of 27 for 308 yards with two touchdown passes and an interception. Smith was one of four players with either four or five catches in the win.

The defense held Colgate to 59 passing yards, the fewest yards a Stanford defense has allowed through the air since holding Oregon to 33 on Oct. 14, 2017.

Kendall Williamson had an interception while Levani Damuni had a team-high 10 tackles. Defensive end David Bailey became the first Stanford true freshman to start a season opener since Owen Marecic in 2007. Bailey finished with two tackles.

Southern California vs Stanford Injury Report

For USC, defensive backs Briton Allen (knee), Zion Branch, Domani Jackson (knee), Joshua Jackson and Adonis Otey, defensive lineman De’jon Benton (arm), offensive lineman Jason Rodriguez, receiver Michael Jackson, linebacker Chris Thompson, and kicker Garth White are questionable. Quarterback Mo Hasan (Achilles) and tight end Jude Wolfe (foot) are out indefinitely.

Stanford starting offensive guard Branson Bragg is questionable.

Southern California vs Stanford Head-to-Head

Stanford has won two of the last three matchups with USC and that includes a 42-28 win as a 17½-point underdog on the road in 2021. The last time the Trojans came to Palo Alto, Stanford came away with a 17-3 win as a 4½-point favorite.

The Cardinal have won five of the last eight matchups with USC. The last time the Trojans won at Stanford came on Sept. 6, 2014, when Stanford was favored by three points.

Southern California vs Stanford Game Information

  • Game: Southern California Trojans 1-0 vs Stanford Cardinal 1-0
  • Location: Stanford Stadium, Palo Alto, California
  • Day/Time: Saturday Sept 10th, 7:30 p.m. ET
  • Southern California vs Stanford Live Stream: ESPN

Southern California vs Stanford Betting Lines

Southern California vs Stanford Prediction

Stanford had two sacks in the win against Colgate and the Cardinal will need to do a better job pressuring the quarterback because Williams can carve up any defense if he is given the time to survey the field.

Southern California has only covered against the college football betting odds in two of its last eight games. The nine-point line seems pretty reasonable for the Trojans to cover.

Something to consider for those who bet online, the total has gone under in four of the last five games between USC and Stanford.

Stanford has failed to cover in its last five home games and is 0-8 against the spread in the last eight contests. The last time the Cardinal opened a season 2-0 came in 2018 when Stanford won the first four games. The game that improved its record to 2-0 was a win against USC.

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

Southern California vs Stanford Edge

Southern California vs Stanford Results

Southern California vs Stanford Game Injuries

Southern California vs Stanford Game Summary

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