Week 12 CFB Picks: BYU, West Virginia Among the Six Best Bets for Big 12
- Get the best college football odds at BetUS.
- BYU is the only undefeated team in the Big 12 and a slight favorite versus Kansas.
- Colorado should beware of Utah.
- Despite losing two straight, Iowa State’s line vs Cincinnati is nearly double digits.
Welcome to the chaos known as the Big 12, and we’re here to make some sweet cash in the college football odds. The turkey and fixins (southern spelling) are not going to pay for themselves.

12. Teams. Left.
What’s Next Is Decided Now. pic.twitter.com/7238vcA9v5
— Big 12 Conference (@Big12Conference) November 13, 2024
Spoiler alert: we’re riding heavy on the underdogs and for good reason. In a conference where upsets like Kansas over Iowa State have become routine, the underdog has become the best value given the parity around the Big 12.
Let’s take a look at my CFB picks for the best bets around the Big 12.
6 CFB Picks in the Big 12 to Consider for Week 12
1. BYU (-2½) Continues Hot Streak by Covering ATS vs Kansas
Kansas has a lot of confidence after upsetting Iowa State. Meanwhile, BYU needed some late magic (and a defensive holding call) to keep their undefeated season alive.
Who ya got to win the Big 12 Championship? 🏆⬇️ pic.twitter.com/sBM0xfWccE
— The Joel Klatt Show: A CFB Pod (@JoelKlattShow) November 13, 2024
This is a much better Jayhawks team than we saw to start the season. Yet, BYU has been a much more consistent team.
The BYU Cougars have been able to survive having a target on the team’s back given the rising expectations. Look for BYU to cover the -2½ ATS in the NCAA football odds.
Bet This Pick: BYU -2.5 (-115)
2. Utah (+11½) Covers Versus Colorado
It will be worth watching how Colorado performs now that the team is in the driver’s seat to make the Big 12 title game. Coach Prime has been all over college football news as he is three wins away from a trip to Arlington for the Buffs to play for the championship belt.
We saw Colorado get off to a shaky start versus Texas Tech. This is a 10 a.m. kickoff so we could be headed for a sleepy start.
Travis Hunter is getting it done on both sides of the ball for @CUBuffsFootball 🔥👏
Here’s how his season stats rank among the Big 12 👀 pic.twitter.com/UDwrcpEIyj
— FOX College Football (@CFBONFOX) November 13, 2024
The BetUS Sportsbook has Colorado as an 11½-point favorite versus Utah. Take the Utah Utes to cover the sizable spread versus the Buffs.
3. Cincinnati (+9½) Hangs With Struggling Iowa State
Iowa State went from being the favorite to win the Big 12 to losing two straight games. I think the Cyclones will stop the skid, but there is no way Iowa State should be nearly a double-digit favorite versus Cincinnati.
Skyline Chili for the win. Bet the Cincinnati Bearcats in our college football picks against the spread vs Iowa State.
Bet This Pick: Cincinnati +9.5
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4. Arizona State (+8) the Right Side Versus Kansas State
Kansas State has been a bit of a disappointment to me this season. Playmaking quarterback Avery Johnson just has not been as consistent as needed for K-State to be the class of the Big 12.
Meanwhile, the Arizona State Sun Devils has outperformed expectations. Star running back Cam Skattebo is expected to return for this Big 12 matchup.
Putting Cam Skattebo highlights on your timeline. Thank us later.
— Unnecessary Roughness (@UnnecRoughness) October 17, 2024
This spread is too high like Taylor Swift’s ticket prices. Take Arizona State to cover ATS in the NCAAF lines versus Kansas State.
Bet This Pick: Arizona State +8
5. West Virginia (+2½) Pulls ‘Upset’ Versus Baylor
We love a good home dog. West Virginia is far from a contender, but we’ve liked the Mountaineers this season.
WVU appears to have found its footing after a challenging early schedule. I’m still not sold on Baylor whose three-game winning streak has mostly been against the bottom of the Big 12.
West Virginia is a 2.5-point underdog versus Baylor in the NCAA football lines. Let’s take the Mountaineers’ moneyline.
Bet This Pick: West Virginia +2.5
6. Bet Houston (+1½) Over Arizona
Let’s keep this one short. Arizona’s offense is not good, and Houston has proved to have one of the best defensive fronts in the conference.
Houston is playing its best ball of the season. We’re riding with H-Town for the cover.
Questions Of The Day
Who is first in the Big 12 standings?
BYU is first in the Big 12 as the only undefeated team.
What is a good Big 12 bet for Week 12?
Take BYU to cover versus Kansas.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.