Cleveland Guardians vs Detroit Tigers Prediction, Picks and Odds 09-16-2025

Note: Manzardo is sidelined due to family emergency list, and he is likely to miss two to three games.

Note: Thomas left the last game in between due to mild plantar fasciitis symptoms, and it remains to be seen if he will be active against the Tigers on Sunday.

Note: Ortiz has been placed on paid leave by the league while he is under investigation for gambling.

Note: Arias exited the matchup with a left ankle sprain, and it is unclear if he will suit up against the Cubs on Tuesday.

Note: Ramirez left the game after getting hit by a pitch on his forearm, and it is unclear if he will be active for Friday's game against the Cardinals.

Note: Hedges has been placed on the 7-day injured list due to a concussion, and there is no timetable for return.

Note: Walters has been added on the 15-day IL due to a Lat injury, and it is unknown how long he will be debilitated.

Note: Thomas has been placed on a 10-day injured list due to a foot injury, and he will miss an undetermined length of time.

Note: Kwan left the game due to a right wrist inflammation, and it remains to be seen if he will be active against the Angels on Friday.

Note: Cecconi is managing a groin injury, and he is unlikely to face the Dodgers on Wednesday.

Note: Santana has been sidelined due to due to left leg tightness, and it is unknown if he will play Monday versus Dodgers.

Note: Gaddis is laid up for a personal reason, and team officials have yet to provide an exact return date.

Note: Brennan has been placed on the 10-day injured list with left forearm inflammation, and he will miss an undetermined length of time.

Note: Lively left the previous game due to an forearm injury, and it is unknown if he will face the Brewers on Tuesday.

Note: Bibee exited the last game due to apparent leg cramping, it is unclear if he will suit up against the Nationals on Monday

Note: Cecconi has been dealing with a left oblique strain, but has began his rehab assignment.

Note: Ramirez left the contest due to a leg injury, and it remains to be seen if he will be active against the Blue Jays on Saturday.

Note: Sewald has landed on the 15-day injured list due to a right shoulder strain, and it is unknown if he will return to action.

Note: Clase is dealing with a shoulder injury, and it is unclear if he will dress against the Red Sox on Friday.

Note: Thomas has been ticketed to the 10-day injured list with a right wrist bone bruise, and he will be sidelined till the late part of April.

Note: Thomas exited the contest with a right wrist contusion, and it is unclear if he will take the field against the White Sox on Thursday.

Note: Ramirez left the match due to a sprained right wrist, and it remains to be seen if he will suit up against the Royals on Sunday.

Note: Bibee is ailing from illness, and it is unclear if he will face Royals on Saturday.

Note: Cecconi has been placed on the 15-day injured list with a left oblique strain, and a timetable for return has yet to be established.

Note: Means has been placed on the 15-day injured list with a elbow injury, and a timetable for return has yet to be established.

Note: Sabrowski has been ticketed to the 15-day injured list with a elbow injury, and there is no timetable for return.

Note: DeLauter underwent hernia surgery, and he will miss an undetermined length of time.

Note: Aleman will miss an undetermined length of time with an abdominal injury, and he will miss an extended period.

Note: Fry landed on the 60-day injury list after suffering an elbow injury, and he will miss an undetermined length of time.

Note: Hentges landed on the 60-day injury list after undergoing a right shoulder anterior capsule repair, and he will miss an undetermined length of time.

Note: Bieber is recovering from an elbow injury, and he will miss an undetermined length of time.

Note: Stephan is recovering from right UCL reconstruction surgery, and a timetable for return has yet to be established.

Note: Guenther has been placed on the 60-day injured list due to a left hip arthroscopy, and he will miss an extended period.

Note: Torres exited the last game in between due to a neck contusion, and it has yet to be established if he will suit up against the Guardians on Sunday.

Note: Gipson-Long has been placed on the 15-day injured list due to a neck strain, and there is no timetable for his recovery.

Note: Carpenter left the game in between due to a right hamstring injury, and his availability against the Nationals is unknown on Tuesday.

Note: Mize left the game due to right leg cramping, and it remains to be seen if he will be active against the Athletics on Tuesday.

Note: Vest exited the game due to an undisclosed injury, and it is unclear if he will play Tuesday versus Pirates.

Note: Carpenter exited the game due to a right hamstring injury, and won't play against the White Sox on Thursday.

Note: Foley has been added to the 60-day injured list after undergoing surgery on his shoulder, and he will miss an extended period.

Note: Jackson has been placed on the 15-day injured list due to a flexor strain, and there is no timetable for return.

Note: Vierling has been added to the 10-day injured list due to a right shoulder inflammation, and he will miss an extended period.

Note: Olson has been placed on the 15-day injured list due to a right ring finger injury, and there is not timetable for return.

Note: Mize has landed on the 15-day injured list due to a hamstring injury, and there is no timetable for return.

Note: Torres is dealing with a hamstring injury, and it is uncertain if he will face the Angels on Saturday.

Note: Carpenter exited the matchup due to right hamstring soreness, and it remains to be seen if he will return to action against the Padres on Monday.

Note: Brebbia has been added to the 15-day injured list due to a right triceps strain, and he will be sidelined till early May.

Note: Brieske has hit the 15-day injury list due to a right ankle inflammation, and a timetable for recovery has yet to be established.

Note: Margot has been added to the 10-day injured list due to a left knee inflammation, and there is no timetable for return.

Note: Rogers is on the 10-day injured list due to a left oblique strain, and he will miss an undetermined length of time.

Note: Torres exited the matchup with a back injury, and it is unknown if he will play Monday versus Mariners.

Note: Madden has been ticketed for the 15-day injured list due to a shoulder injury, and he will miss an undetermined length of time.

Note: Perez is dealing with a lower back injury, and he will be sideline till the late part of April.

Note: Torres is dealing with a right quadriceps contusion, and it is unclear if he will suit up for the opening day contest against the Dodgers on March 27th.

Note: Meadows is dealing with a right arm injury, and it has yet to be determined if he will suit up for the opening day contest against the Dodgers on March 27th.

Note: Gipson-Long has been placed on the 60-day injured list with a Left hip injury, and he will miss an undetermined length of time.

Note: Vierling is dealing with a strained right rotation cuff muscle, and he is not projected to be active for the opening day contest against the Dodgers on March 27th.

Note: Baddoo underwent surgery to address a hamate bone fracture in his right hand, and team officials have yet to provide an exact return date.

Note: Lange has hit the 60-day injury list while recovering from late surgery, and a timetable for recovery has yet to be established.

Note: Cobb is dealing with right hip inflammation, and he isn't likely to be ready for the start of the season.