San Diego Padres vs Houston Astros Prediction, Picks and Odds 04-20-2025

Note: Bergert exited the last matchup due to a forearm injury, and it is unknown if he will face the Nationals on Wednesday.

Note: Bogaerts is out of lineup due to a left shoulder soreness, and he is not projected to face the Reds on Friday.

Note: Suarez is facing a two games suspension, and it remains to be seen if he will be active against the Reds on Saturday.

Note: Merrill exited the previous game due to a head injury, and it is undetermined if he will suit up against the D-backs on Sunday.

Note: Arraez is dealing with a knee soreness, and it is unknown if he will play Friday versus Brewers.

Note: Bogaerts is managing with a left shoulder soreness, and it has yet to be determined if he will participate against the Brewers on Friday.

Note: Sheets left the last match due to an undisclosed injury, and it has yet to be established if he will be available against the Giants on Monday.

Note: Heyward has been landed on the 10-day injured list due to a left oblique strain, and he will remain out of the lineup until the early part of June.

Note: King has been out of lineup due to right shoulder stiffness, and it is unclear if he will play Braves on Sunday.

Note: Merrill is ailing with an illness, and it remains to be seen if he will return to action against the Angels on Monday.

Note: Cease left the last game due to an forearm injury, and it is unknown if he will play Friday versus the Rockies.

Note: McCoy has landed on the 10-day injured list due to a sprained finger on his left hand, and he will be sidelined till mid of May.

Note: Gillaspie has been placed on the 15-day injured list with an Oblique injury, and there is no timetable for recovery.

Note: Arraez is placed on the 7-day injured list with a concussion, and he will miss an undetermined length of time.

Note: Heyward is dealing with a knee injury, and it is unclear if he will play against the Astros on Saturday.

Note: Lockridge has been placed on the 10-day injured list with a left hamstring strain, and there is no timetable for recovery.

Note: Cronenworth exited the contest due to cramping in his ribs, and it remains to be seen if he will return to action against the Athletics on Wednesday.

Note: Tatis exited the matchup with a left shoulder discomfort, and it is unknown if he will play against the Athletics on Wednesday.

Note: Merrill has been placed on the 10-day injured list with a right hamstring strain, and there is no timetable for recovery.

Note: Machado exited the game due to calf tightness, and it is unclear if he will face Braves on Sunday.

Note: Brito has been landed on the 15-day injured list with right forearm strain, and team officials have yet to provide an exact return date.

Note: Waldron has been placed on the 15-day injured list with a Left oblique muscle strain, and team officials have yet to provide an exact return date.

Note: Darvish is bothered by an elbow injury, and team officials have yet to provide an exact return date.

Note: Hoeing is nursing a sore right shoulder, and he is not expected to feature in the lineup for the opening day contest against the Braves on March 27th.

Note: Reynolds is dealing with a stress reaction in his right foot, and he is not expected to suit up for the opening day matchup against the Braves on March 27th.

Note: Musgrove will miss an extended period due to Tommy John surgery he underwent in October, and he is without a definitive timetable for return.

Note: Meyers missed the last game due to a right calf tightness, and it remains to be seen if he will be active against the Guardians on Tuesday.

Note: Walker has been placed on the paternity list, and he is likely to miss two to three games.

Note: Guillorme has been placed on the 10-day injured list due to a right hamstring strain, and a timetable for return has yet to be established.

Note: Pena left the contest in between due to a left rib soreness, and it has yet to be established if he will return to action against the Cubs on Saturday.

Note: Dubin has been landed on the 15-day injured list with a right forearm strain, and he will miss an undetermined length of time.

Note: Leon has been placed on the 60-day injured list with a knee injury, and he will miss an undetermined length of time.

Note: Rodgers has been placed on the 10-day injured list due to an oblique injury, and it is unknown how long he will be idle.

Note: McCullers Jr. has been placed on the 15-day injured list with a right foot sprain, and team officials have yet to provide an exact return date.

Note: Melton has been landed on the 10-day injured list with right ankle sprain, and he will miss an extended period.

Note: Paredes exited the previous game due to a leg injury, and it is uncertain if he will play against the Twins on Friday.

Note: Smith is out of the lineup due to an illness, and it is unknown if he will face Guardians on Saturday.

Note: Dezenzo exited the game due to left hand discomfort, and it is unknown if he will face Rays on Sunday.

Note: McCormick has been landed on the 10-day IL due to a left oblique strain, and he will miss an extended period.

Note: Walker has been sidelined due to hand injury, and it is unknown if he will face Rays on Thursday.

Note: Blanco is bothered by right elbow soreness, and it is unclear if he will play against the Mariners on Thursday.

Note: Altuve exited the last game due to a right hamstring tightness, and it is uncertain if he will be available against the Royals on Monday.

Note: Wesneski has been placed on the 15-day injured reserve with elbow injury, and he will miss an undetermined length of time.

Note: Alvarez is dealing with a hand injury, and it is uncertain if he will play against the Brewers on Monday.

Note: Abreu has been placed on the paternity list, and he is expected to miss two to three games.

Note: Rodgers is dealing with a hip injury, and it is unclear if he will play against Cardinals on Wednesday.

Note: Rodgers is battling with left hip soreness, and it is unclear if he will dress against the Angels on Sunday.

Note: Arrighetti has been landed on the 15-day with a fractured right thumb, and he will miss an extended period.

Note: Dubin has been lands on 15-day injured list with a right shoulder inflammation, and he will miss an undetermined length of time.

Note: France has been added to the 60-day injured list while recovering from right shoulder surgery, and he will miss an undetermined length of time.

Note: Wesneski suffered a left foot injury, and it remains to be seen if he will be active for the opening matchup against the Mets on Thursday.

Note: Whitley is hampered by a bone bruise in his left knee, and he is not expected to be active for the opening matchup against the Mets on Thursday.

Note: Walker is hobbled by a sore left oblique, and it remains to be seen if he will be active for the opening matchup against the Mets on March 27th.

Note: Leon is hampered by a Grade 1 left MCL strain, and he is not expected to be active for the opening matchup against the Mets on March 27th.

Note: Trammell will miss an extended period due to a calf injury, and team officials have yet to provide an exact return date.

Note: Ort is dealing with an oblique injury, and it is up in the air if he will dress against the Mets on March 27th.

Note: Garcia is fighting off an elbow injury, and he is not expected to be active for the opening matchup against the Mets on March 27th.

Note: Javier is nursing an elbow injury, and it is up in the air if he will dress against the Mets on March 27th.

Note: McCullers is dealing with a forearm injury, and he is not going to suit up for the opening contest against the Mets on March 27th.