Angels vs Padres Prediction, Picks and MLB Prop Bets, Wednesday, 5/14: Back Tatis for 2+ Runs/RBIs

The San Diego Padres were in danger of losing just their second home series of the season before scoring two runs in the eighth inning to set up Fernando Tatis Jr. to win Tuesday’s game with a walk-off home run. The BetUS sportsbook lists the Padres as the home favorite in the series finale with some tempting MLB home run props.

The Padres are 11-4 on the run line as the home favorite. The Angels have covered in just seven of 18 games as the road underdog. Keep that in mind when making MLB picks.

The MLB betting odds have the Padres at -181 to improve to 16-5 at home. The Angels offer some value at +159 to win their first road series in more than a month.

The MLB futures bets have the Padres (+1800) with the eighth-shortest odds of winning the World Series. The Angels are well back at +25000 in the championship odds.

Angels vs Padres Prediction Today, May 14, 2025

My prediction

• San Diego Padres To Cover (-1½)

San Diego probable starter Randy Vasquez has had mixed results in his last two starts. He has only allowed three runs in 11 innings. However, he walked five batters in five innings in one start and allowed two home runs the next time out.

The Angels have lost four of the last five games started by Kyle Hendricks.

Before winning the series opener, the Angels had dropped nine consecutive road games with a -36 run differential in those MLB matchups.

The @Angels rally for 6 runs in the 9th, including a tie-breaking grand slam, to stun the Padres. pic.twitter.com/4coIkH5Kuz

— MLB (@MLB) May 13, 2025

Take the Padres to win and cover at home when making MLB picks.

Bet on Padres -1½ Runline (+110)

• Angels vs Padres Over 8½ Runs

The Angels and the Padres made MLB news as they have combined for six home runs in the first two games of the series. There have been 48 combined runs scored in the four road starts by Hendricks.

Even though both pitchers have ERA under 3.00 in May, take this MLB matchup to land over.

Bet on Angels vs Padres Over 8½ Runs

Angels vs Padres Prop Picks and Best Bets

• Fernando Tatis Jr. 2+ Runs + RBIs (+129)

Tatis is 9-for-29 with 10 runs and eight RBIs during a seven-game hitting streak. He has homered in each of the first two games of the series.

FERNANDO TATIS JR. WALKS IT OFF! pic.twitter.com/cjQHQcHPJ2

— MLB (@MLB) May 14, 2025

I know that Tatis is only 1-for-12 in his career against Hendricks, but I still like the +129 odds for Tatis to have 2+ runs + RBIs when making best MLB prop bets today.

Bet on Fernando Tatis Jr. to have 2+ Runs + RBIs (+129)

• Yoan Moncada 2+ Total Bases (+149)

Yoan Moncada’s first season with the Angels got off to a slow start. However, he is starting to rake in May with five of his eight hits going for extra bases.

He is hitting .286 and slugging .643 over his last eight games. It could be worth a shot to take the +149 odds for Moncada to have 2+ total bases from hits as one of the MLB prop picks.

Bet on Yoan Moncada 2+ Runs + RBIs (+149)

• YRFI (-104)

Hendricks has allowed four first-inning runs in his first seven starts of the season. He is also 0-2 with an ERA of 7.00 on the road. Vasquez had walked seven and given up three runs in the first inning in seven starts.

San Diego is tied for third in the majors with 31 first-inning runs. The Angels are one of five teams with at least 10 home runs in the first inning. Keep that in mind when making MLB expert picks.

Bet on Score on First Inning – YES (-104)

Angels vs Padres How to Watch

• Game: Angels (17-24) vs Padres (26-15)
• Date/Time: Wednesday, May 14, 9:40 p.m. ET
• Location: Petco Park, San Diego
• Angels vs Padres Live Stream: MLB.tv

Click here for Angels vs Padres betting trends.

Get More MLB Game Picks, Expert Analysis and Best Bets

• Angels vs Padres Same Game Parlay Picks, Wednesday, 5/14: Bet San Diego (-1.5)

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.