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Bet the Over for MLB Game Picks in Cardinals vs Padres

The St. Louis Cardinals and San Diego Padres clash for the first time this season in the series opener on Monday. St. Louis got its season off to a slow start, dropping its first series with the Dodgers, despite nearly splitting the set after a close final game, while the Padres bounced back from a couple of rough outings with the Giants to win their final game and even the series. The Cardinals and Padres look to start the week on a high note, while the MLB odds list the Cardinals at -101 on the road.


Bet the Over for MLB Game Picks in Cardinals vs Padres
Bet the Over for MLB Game Picks in Cardinals vs Padres

Cardinals vs Padres Game Information

  • Game: St. Louis Cardinals (1-3) at San Diego Padres (3-3)
  • Location: Petco Park, San Diego
  • Date/Time: April 1, 9:40 p.m. ET
  • Cardinals vs Padres Live Stream: MLB.tv


The San Diego Padres will try to build on their last win when they host the St. Louis Cardinals on Monday at Petco Park. MLB run lines for April 1 have the Cardinals at -101 on the road, with the BetUS sportsbook setting the total at 8½ runs.


Cardinals vs Padres Odds and Spreads


  • The over is 5-0 in the Padres last five overall.
  • The over is 4-0 in the Padres last four games versus a right-handed starter.
  • The over is 4-0 in the Padres last four on grass.
  • The over is 4-0 in the Padres last four home games.
  • The total has gone over in five of San Diego’s last six games against an NL opponent.


Cardinals vs Padres Over/Under Pick: Over 8½ Runs

Neither teams’ pitching has been particularly impressive to start the season, and both offenses should find enough success to hit the over yet again in this matchup.

Though the Padres’ offense finished strong in their final game against San Francisco, scoring 13 runs, a big performance was necessary, as they allowed an average of 6.3 runs in the four-game series. San Diego’s bullpen struggled, giving up 15 of the 25 total runs allowed in the series to the Giants while having a 6.33 ERA.

However, with Matt Waldron starting for San Diego, the Cardinals will not only have a solid opportunity to score against its bullpen, but against him as well. Waldron, in his second season, finished 2023 with a 4.35 ERA, giving up 20 earned runs and nine homers.

Though the Cardinals should find more scoring after averaging 3.5 runs in their series with the Dodgers, they are also due to give up a few. St. Louis’ bullpen didn’t do it any favors against Los Angeles either, recording a 6.09 ERA while allowing 23 runs in the series. With the Padres already hitting seven homers in their last series with San Francisco and starter Kyle Gibson struggling at times last season with a 4.73 ERA, there should be plenty of offense in this opener.

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Cardinals vs Padres Player Prop: Manny Machado 1+ Runs+RBI (-157)

Machado has gotten his season off to a solid start, already hitting two home runs while already earning seven RBIs as well to lead the Padres. Machado has had at least one run in all but one game, getting seven in six games.

In a game that should be more of a shootout, expect Machado to find home plate at least once to help the Padres beat the Cardinals.



Cardinals vs Padres Prediction

Padres 6, Cardinals 4



Questions Of The Day

Who are the starting pitchers in the game?

Kyle Gibson is expected to start for St. Louis while Matt Waldron will be on the mound for San Diego.

What is the Padres’ record in San Diego?

The Padres have a 2-2 record at Petco Park.

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