Brewers vs Pirates Prediction, MLB Prop Bets and Parlay Picks for Friday, 5/23

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• Take a Skenes over 6.5 strikeouts at value +112 odds.
• Consider a bet on slumping Bryan Reynolds to get 2+ total bases.

Brewers vs Pirates Prediction and Best Bets Today, May 23

My prediction

• Milwaukee Brewers +1.5 Runs (-210)

It’s a Friday night in Pittsburgh and Paul Skenes is on the mound, which is about as big as it gets at PNC Park all season. However, the Pirates are so bad offensively that they’re 3-7 in games where Skenes – one of the top pitchers in the game – is on the mound. And in this case, the Brewers are countering with a very good arm of their own in Freddy Peralta. Both are solid candidates to get a spot in your MLB player props today.

Size up the MLB betting odds, but consider the road underdogs against a team that is 3-13 against the run line when favored.

Christian Yelich slugs 2 home runs, and the @Brewers have won 4 of their last 5. pic.twitter.com/yFPWJ6EftG

— MLB (@MLB) May 23, 2025

Bet on Brewers +1.5 Runs (-210)

• Brewers vs Pirates Under 7 Runs (-115)

This is a low number to have to squeeze under. However, these teams both go under 60.4% of the time and have their best pitchers on the mound, so it’s very conceivable to see a 3-2 final one way or another. Include this in your best MLB parlay bets today and cheer on both Peralta and Skenes.

Bet on Brewers vs Pirates under 7 Runs (-115)

Get More MLB Game Picks, Expert Analysis and Best Bets

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My Best Prop Bets

• Paul Skenes Over 6.5 Strikeouts (+112)

Skenes’ strikeout rate has nosedived from his rookie year, but he still gets one per frame and has lasted at least six innings in eight of his last nine starts. Current Brewers hitters are 0-for-15 with seven strikeouts and zero walks against the 22-year-old, so it’s clearly been a very one-sided situation that’s been filled with high K totals.

This is a great addition to your MLB parlay picks today.

Paul Skenes Incinerating Bryce Harper.

99, 99, 100 🔥🔥🔥 pic.twitter.com/XKFcIWsCmu

— Rob Friedman (@PitchingNinja) May 18, 2025

Bet on Paul Skenes Over 6.5 Strikeouts (+112)

• Bryan Reynolds to Record 2+ Total Bases (+127)

We don’t expect much offense, but this guy is a candidate to do some damage and should be considered for any MLB prop picks today. He was 2-for-3 in Thursday’s 8-5 loss to the Brewers and has an RBI in three straight games as he tries to dig out of a season-long slump. Facing Peralta might help, as Reynolds is 12-for-31 (.387) against the righty.

Reynolds’ struggles have kept him off most MLB expert picks so far. Here’s an opportunity to get him involved.

Bet on Bryan Reynolds to Record 2+ Total Bases (+127)

Brewers vs Pirates Same Game Parlay Picks Today, May 23

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Brewers vs Pirates How to Watch

• Game: Milwaukee Brewers (25-26) vs Pittsburgh Pirates (17-34)
• Date/Time: May 23, 6:40 p.m. ET
• Location: PNC Park, Pittsburgh, PA
• Brewers vs Pirates Live Stream: MLB.tv

Get the latest Brewers vs Pirates betting trends here.

Brewers vs Pirates MLB FAQs

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.