Brewers vs Pirates Predictions, Game Preview, Live Stream, Odds & Picks April 27
Brewers Try to Hang Onto NL Central Top Spot vs Pirates
Brewers Hoping to Stay Perfect vs Pirates
The Milwaukee Brewers look for a fifth straight victory over the Pittsburgh Pirates when the two teams continue their three-game series on Wednesday night. Milwaukee took the series opener on Tuesday to improve to 4-0 against the Pirates this season and move into first place in the NL Central by a half-game over the second-place St. Louis Cardinals. Pittsburgh has lost two of its last three and is in third place in the division standings, 1½ games behind the Cardinals and a game ahead of the fourth-place Chicago Cubs. The Pirates will be hungry for their first win over the Brewers, but check out our in-depth preview of this contest to help you decide how you want to bet online.
Let’s check the latest MLB picks, stats, injury reports, and MLB odds for Brewers vs Pirates. We have plenty of MLB predictions.

Adames Leads Brewers to Series-Opening Win
The Milwaukee Brewers have had their offensive troubles this season, but that wasn’t the case on Tuesday night. Milwaukee put a season-high 12 runs on the board in a 12-8 win, led by Willy Adames’ two home runs and career-high seven RBIs.
“I’ve been working a lot,” Adams said after Tuesday’s win. “I was happy to see some results. It’s good to have a night like that as a group.”
Adames had a two-run home run in the first and a three-run blast in the sixth, the first multi-homer game of his career. Adames had four hits in the game and raised his season batting average to .239. He also has three doubles, four home runs, 12 RBIs and 12 runs scored.
Catcher Omar Narvaez had a good night as well, going 2-for-5 with two RBIs and a run scored. He’s batting .237 with a double, a home run, five RBIs and four runs scored in part-time duty.
On the mound for Wednesday’s contest will be left-hander Aaron Ashby, who is looking for his first win of the season. Ashby has started once in four appearances this season and is coming off a rough showing against the Philadelphia Phillies on Friday, as he went 2⅓ innings and allowed three runs on five hits. He has an ERA of 3.18 in 11⅓ innings of work in 2022.
Pirates Need More From the Mound
The Pittsburgh Pirates are not getting consistent pitching from their staff, as the 12 runs given up on Tuesday night weren’t even the most allowed by the team this week. The Chicago Cubs scored 21 runs on Pittsburgh on Saturday, so clearly the team is having its troubles getting opponents out.
Right-hander Bryse Wilson will take his shot at shutting down the Milwaukee Brewers bats on Wednesday. Wilson is 0-0 with a 6.35 ERA in three starts this season. He has yet to go more than 4⅓ innings, allowing at least two runs in every outing.
Lost in the Brewers’ explosion at the plate, Pittsburgh had eight runs on 13 hits in Tuesday’s loss. Shortstop Kevin Newman was 2-for-3 with a two-run single in the fifth, but he was removed from the game due to left groin tightness, so his status for Wednesday is up in the air.
Third baseman Ke’Bryan Hayes has been the most consistent hitter for the Pirates, coming into Wednesday tied for fourth in the majors with a .364 batting average. Hayes was 3-for-3 with a double, an RBI and two runs scored in Tuesday’s game. He has six doubles, five RBIs and eight runs scored this season.
Brewers vs Pirates Head-to-Head
The Milwaukee Brewers’ 4-0 lead in the current season series is a bit of a continuation of last year’s matchups between these two NL Central rivals. Milwaukee took 14 of 19 games from the Pittsburgh Pirates in 2021, including eight of the 10 matchups in Pittsburgh.
The Pirates were more competitive in 2020, splitting the 10 games between the clubs. The MLB lines see the Brewers continuing to dominate in this series, giving them the edge in Wednesday’s contest.
Brewers vs Pirates Game Information
- Game: Brewers (11-7) vs Pirates (8-9)
- Location: PNC Park
- Day/Time: Wednesday, April 27th 6:35 p.m. ET
- Live stream: MLB.tv
Brewers vs Pirates Betting Lines
Brewers vs Pirates Prediction
The Milwaukee Brewers are putting things together right now and playing against a team they have yet to lose to this season. Look for another win by Milwaukee over the Pittsburgh Pirates in the second game of this series.
When making your MLB picks, take Milwaukee to pick up another road win.