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Cardinals vs Reds Predictions, Game Preview, Live Stream, Odds & Picks, April 22nd

Cards Want to Solidify First, While Reds are on 9 Game Skid

Cardinals vs Reds in NL Central Match Up

The St. Louis Cardinals come into Friday’s series opener with a slight winning percentage lead in the NL Central while the Cincinnati Reds not only have the worst record in the NL Central but in all of Major League Baseball. It’s not hard to see who has the upper hand in this match-up.

Let’s check the latest MLB Picks, stats, injury reports, and MLB Odds for Cardinals vs Reds. We’ve plenty of MLB Predictions.

Cardinals vs Reds Predictions, Game Preview, Live Stream, Odds & Picks, April 22nd

Cards Want Some Distance

In what could prove to be a volatile division without a clear frontrunner, the St. Louis Cardinals are looking to take three games from the division-rival Reds while the other NL Central teams perhaps drop a game or two over the weekend.

In the overall scheme of things, the Cardinals and Brewers appear to have the best shot at the NL Central title, but taking three games from the floundering Reds are needed to try to gain some early distance from the Brew Crew. Cardinals hitters will have their hands full early on with flame-throwing rookie, Hunter Greene on the mound.

The key to this game for the Cardinals will be working with Greene to throw quality pitches and get to the bullpen as quickly as possible. If they can keep the score close early on, they should have no problem shutting the door once they get to the Reds’ bullpen.

Greene Bright Spot for Woeful Reds

Hunter Greene will make his home debut for the Cincinnati Reds on Friday night, looking to continue firing in pitches at over 100 mph. While the Reds have managed just two wins this season, we are hard-pressed to think that Greene has the ability to pitch a complete game. The Reds are not going to jeopardize their young talent just to get off a nine-game losing streak.

Sooner or later the Reds have to get off the schneid. The Reds have been huge underdogs in most of its games but in this game, with Greene on the mound, the line is much closer than it has been previously. Look for those MLB lines to stay closer in this matchup.

The offense will need to get their act together and give Greene some run support to bring a win home. The Cardinals are no pushover and they will make the Reds work for a win at every turn.

Cardinals vs Reds Head-to-Head

The divisional foes play often, (19 matchups in 2021) the Reds came out ahead 10-9 in the season series, however, the Reds are a shell of their former selves from 2021, having shipped most of their productive veterans off to other teams in return for young talent.

Hunter Greene vs. Steven Matz is the pitching matchup. Greene the fireballer will keep hitters on their toes while the veteran Matz will look to carry on from a solid last performance in which he picked up the win against the Brewers.

Cardinals vs Reds Game Information

  • Game: Cardinals (7-4) vs Reds (2-11)
  • Location: Great American Ball Park, Cincinnati, OH
  • Day/Time: Friday, April 22nd. 6:40 p.m. ET
  • Cardinals vs Reds Live Stream: MLB.tv

Cardinals vs Reds Betting Lines

Cardinals vs Reds Prediction

While it seems like this should be a pretty straightforward online gambling prediction with a contender versus a cellar dweller, the line on this game is a lot tighter than one might think. The Cardinals have been very good at covering the run line this year – when they win, they cover. At +125 to cover 1 ½ runs over a struggling Reds, that would be a solid bet to earn money on.

You could take the Reds Moneyline at +113, but the risk is not worth the reward on that bet. If it was higher, then, by all means, take that bet because the Reds are bound to win one of these days.

When you bet online, take the Cardinals to cover the run line at -1 ½ +135 over the scuffling Reds.

Pick: St. Louis Cardinals -1 ½ +135

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