Cubs vs Mets Prediction, Picks and MLB Prop Bets, Saturday, 5/10: Take Mets To Cover As A Home Favorite

The New York Mets delivered in the MLB home run props with three in the first four innings to take the series opener versus the Chicago Cubs on Friday. Tylor Megill is set to get the ball on Saturday with the Mets having a chance to win the first series of the season between the teams.

The Mets have won eight of their last 12 games against the Cubs. The MLB lines today have the Mets at +135 on the -1.5 moneyline and -145 to win outright. The Cubs are priced at +130 to even the series.

The Mets (+900) are second only to the Los Angeles Dodgers among National League teams in the odds of winning the World Series, making them a solid MLB futures bet. The championship odds for the Cubs have moved from +2800 to +1600 since the start of the season.

Cubs vs Mets Prediction Today, May 10, 2025

My prediction

• Run Line Pick: New York Mets -1.5 runs (+135)

The Mets got back to their winning ways at home Friday after dropping the final two games at Citi Field in their previous series with Arizona. Francisco Lindor and Juan Soto, the first two batters in the Mets’ lineup, each homered and had five hits. It’s hard to beat the Mets when that happens.

It is looking like a bullpen game for the Cubs, with Brad Keller expected to make his first start of the season. Top prospect Cade Horton could be among the bullpen options.

Brad Keller is set to start tomorrow, Craig Counsell said. Cade Horton will be active, but Counsell described it as “essentially” a bullpen game.

— Maddie Lee (@maddie_m_lee) May 10, 2025

The Mets are now 14-3 at home. Only the Cardinals and the Dodgers have more home wins among National League teams. Take the Mets to add to that win total when making your wagers on this game.

Bet on New York Mets -1.5 runs (+135)

• Over/Under Pick: Chicago Cubs Over 8.5 (-105)

There were six solo home runs hit in the series opener, overshadowing the fact that the Cubs and Mets combined to go 2-for-14 with runners in scoring position. The Cubs have scored the most runs in the majors and the MLB schedule offers them an immediate chance to bounce back after being held to two runs or less for the third time in the last five games.

Bet on Cubs vs Mets Over 8.5 (-105)

Cubs vs Mets Prop Picks and Best Bets

• Juan Soto 2+ Total Bases (+110)

Soto delivered on the odds that had him with at least two total bases in Friday’s 7-2 win thanks to a solo home run in his second time up to bat. Soto continues to make MLB news, as he is third among qualified players with an OPS of 1.407 in May.

Juan Soto CRUSHES one 434 feet!

His third home run in his last two games 😤 pic.twitter.com/JmeHvcABrG

— MLB (@MLB) May 10, 2025

Keep riding Soto while he is swinging a hot bat and jump on the +114 odds for Soto to have 2+ total bases from hits when making best MLB prop bets today.

Bet on Juan Soto 2+ Total Bases (+110)

• Pete Crow-Armstrong 1+ Runs+RBIs (+108)

Pete Crow-Armstrong was a first-round pick by the Mets who had a hit and a walk in the series opener after coming through with two hits in the final road game against the Mets in 2024.

Crow-Armstrong is one of three Cubs with at least 25 runs and RBI this season. It could be worth a shot to take the +110 odds for Crow-Armstrong to have 1+ runs+RBIs as one of the MLB player prop picks.

Bet on Pete Crow-Armstrong 1+ Runs+RBIs (+108)

• Cubs vs Mets NRFI (-104)

Lindor homered on the third pitch in the bottom of the first inning to reward those going with the YRFI bets on Friday. When looking at the MLB betting trends, however, Megill has been lights out in the first inning with two hits and no runs allowed with nine strikeouts in the opening frame. The Mets have just 15 first-inning runs this season. Keep that in mind when making your picks.

Bet on Score on First Inning: No (-104)

Cubs vs Mets How To Watch

• Game: Chicago Cubs (22-17) vs New York Mets (25-14)
• Date/Time: Saturday, May 10, 7:15 p.m. ET
• Location: Citi Field, Queens, NY
• Cubs vs Mets Live Stream: MLB.tv

Click here for the latest Cubs vs Mets betting trends.

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Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.