New York Yankees
Cubs vs Padres Prediction, Picks and MLB Prop Bets for April 14: Bet San Diego (-147) to Stay Perfect at Home
- Take the Over 7.5 in Cubs vs Padres predictions.
- Back Fernando Tatis Jr. 1+ runs + RBIs as one of the best MLB prop bets.
- Make bank with our 2025 MLB picks! Join with our promo code HUDDLE125.
Cubs vs Padres MLB Odds Today
Cubs vs Padres Prediction Today, April 14, 2025
My prediction
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Moneyline Pick: Padres (-147)
In the MLB news today, the Padres are undefeated at home (10-0) and haven’t allowed a run in three straight games. While their offense isn’t as explosive as the Cubs on paper, they’ve been efficient and disciplined. Jamseon Taillon has a 6.06 ERA and could struggle early in a tough road spot. Petco magic is real — I’ll back San Diego on the MLB money line.
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Over/Under Pick: Over 7.5 Total Runs (-105)
We’ve got two starters with a combined ERA of 14.04, per Cubs vs Padres stats. Dylan Cease has a 1.57 WHIP while Taillon has allowed 18 hits in 16.1 innings. Even if the bullpens settle down late, both offenses rank top-five in batting average or slugging.
Plus, the MLB futures odds on these lineups are short for a reason — they can mash. This number feels too low in a game where five runs could be scored by the 4th inning.
Bet on Cubs vs Padres Over 7.5 Total Runs (-105)
Cubs vs Padres Prop Picks and Best Bets
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Fernando Tatis Jr. 1+ Runs+RBIs (-164)
Fernando Tatis Jr. is batting .351 with a .415 OBP and is regularly hitting in front of Jackson Merrill and Jake Cronenworth. He’s crossed the plate 13 times in just 57 at-bats and draws a great matchup against Taillon, who’s already allowed four4 home runs. With the Cubs’ pitching prone to extra-base hits, Tatis should be on the basepaths all night. Among the best MLB prop bets, this one stands out.
Fernando Tatis Jr. closes out the game with an incredible catch! 😤 pic.twitter.com/cPnXC256hK
— MLB (@MLB) April 13, 2025
Bet on Fernando Tatis Jr. 1+ Runs+RBIs (-164)
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Cubs to Have the Highest Scoring Inning (+170)
The Cubs average 6.44 runs per game and lead MLB in walks and plate appearances. Even with the Padres’ elite bullpen, Cease is vulnerable early and Chicago has shown it can post crooked numbers in a hurry — just ask the Dodgers. If you’re looking for MLB game predictions with some value, this one could cash in a single big inning.
Bet on Cubs to Have the Highest Scoring Inning (+170)
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Yes Run First Inning (+109)
The Cubs and Padres both rank in the top-10 for first-inning scoring, and both starters are struggling to avoid early damage. Chicago has strong production at the top while San Diego’s been clutch at home. Given the trends and shaky command from both arms, this is one of the sharper MLB prop picks today.
Bet on Yes Run First Inning (+109)
Cubs vs Padres How to Watch
- Game: Cubs (11-7) vs Padres (13-3)
- Date/Time: Monday, April 14, 9:40 p.m. ET
- Location: Petco Park, San Diego, CA
- Padres vs Nationals Live Stream: MLB.TV
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets
