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Diamondbacks vs Astros Prediction, Preview, Stream, Odds & Picks, Sep, 28.

American League Cy Young Favorites on Display

Astros Look to Sweep Series

The Houston Astros (102-53) can clinch the American League’s best record with a victory over the Arizona Diamondbacks (71-83) on Wednesday. Houston won Tuesday’s series opener 10-2. It’s hard to imagine Arizona finding the motivation to beat one of the best teams in baseball, especially with AL Cy Young Award favorite Justin Verlander on the mound for the Astros. But the Diamondbacks counter with Zac Gallen, who is also having a Cy Young-worthy season.

Let’s check the latest MLB odds, stats, injury reports, and MLB lines for Diamondbacks vs Astros. We’ve plenty of Vegas MLB odds for you to consider.

Diamondbacks vs Astros Prediction, Preview, Stream, Odds & Picks, Sep, 28.
Diamondbacks vs Astros Prediction, Preview, Stream, Odds & Picks, Sep, 28.

Gallen Gives Arizona a Chance

Arizona Diamondbacks are a far inferior team, but it’s not all bad news for Arizona on Wednesday. Zac Gallen (12-3, 2.46) is on the bump as the lone bright spot in this Diamondbacks’ rotation. Gallen is one of the best starters in the MLB, ranking 17th in strikeouts, sixth in ERA and second in WHIP (0.89). His record is a testament to his elite status, considering that he pitches for a sub-.500 club.

Gallen is the one player in Arizona who has a chance to make a big difference in the outcome of this game. Gallen has a stellar .227 batting average against the current Astros with four extra-base hits in 44 at-bats. It will be the first time he and the Astros will face off this season.

While that is all well and good, it doesn’t erase the fact that most of Arizona’s team is struggling at the plate. We expect Gallen to keep the Astors in check, but it won’t matter much if their offense fails to score. This is a problem considering their best hitter is Ketel Marte, with a .242 average. Christian Walker is a threat with 36 home runs but struggles to hit for average against right-handers, and the Astros have a pretty good one taking the mound Wednesday.

Houston’s Verlander Getting Better With Age

Justin Verlander (17-4, 1.82) continues to dominate the MLB despite nearing the big 4-0. The right-handed future first-ballot Hall of Famer leads the league in ERA and WHIP (0.84) while ranking second in wins. His ERA in September is a microscopic 1.64, and he hasn’t given up more than two runs in a start in more than a month. As far as the rest of the Astros go, they are as solid as a team gets. Houston Astros is 7-2 in its last nine games, averaging 5.8 runs during that span. They are also one of the only two teams (Dodgers) with at least 100 wins. There is little reason to expect the Astros to struggle too much in this two-game series finale.

Diamondbacks vs Astros Head-to-Head

Wednesday will be the fourth game between the interleague teams, with Houston holding a 2-1 series lead. The Diamondbacks are 2-1 against the spread, with the O/U at 1-2.

Diamondbacks vs Astros Game Information

  • Game: Diamondbacks (71-84) vs Astros (102-53)
  • Location: Minute Maid Park, Houston
  • Day/Time: Wednesday, Sep 28, 8:10 p.m. ET
  • Diamondbacks vs Astros Live Stream: MLB.tv

Diamondbacks vs Astros Lines

Team Run Line Moneyline Total Team Total
Arizona Diamondbacks

Z. Gallen -R

+1½ -145 +155 6½Evo 2½-105o


Houston Astros

J. Verlander -R

-1½ +125 -175 6½-120u 3½-125o


The odds in this chart are based on the time of publication. They are subject to change.

Diamondbacks vs Astros Prediction

We appreciate that Gallen givest the Diamondbacks their best chance to win as a Cy Young contender. But even Gallen will be outgunned on Wednesday with Verlander on the opposite side. There exist matchups where fading Verlander makes sense from time to time. But a game against the Diamondbacks is not one of them.

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

Diamondbacks vs Astros Edge

Diamondbacks vs Astros Results

Diamondbacks vs Astros Game Injuries

Diamondbacks vs Astros Game Summary

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