Diamondbacks vs Dodgers Prediction, MLB Prop Bets and Parlay Picks for Wednesday, 5/21

Oscar Diaz

· May 21 - 4 minutes read

Arizona Diamondbacks

Los Angeles Dodgers

+1½ +105

Run Line

-1½ -125

+198

Moneyline

-230

O 9½ -110

Total

U 9½ -110

Team Total

O 5½ -115 U 5½ -115

Place your Bets on Diamondbacks vs Dodgers at BetUS Sportsbook!

Diamondbacks vs Dodgers Prediction, MLB Prop Bets and Parlay Picks for Wednesday, 5/21 — Los Angeles Dodgers First Baseman Freddie Freeman (5) | Kirby Lee-imagn Images

Make bank with our top MLB picks! Join with our promo code HUDDLE125.
Dodgers -135 are the moneyline pick vs Arizona
Include under 9 runs (+100) in Diamondbacks vs Dodgers picks

Diamondbacks vs Dodgers Prediction and Best Bets Today, May 21

My prediction

Moneyline Pick: Los Angeles Dodgers (-135)

The Los Angeles Dodgers have lost four of their last five in the MLB betting market, and three came against Shohei Ohtani’s old team. They’ve seen Arizona starter Corbin Burnes recently and should make adjustments. The Dodgers rank in the top three in total bases and OPS. Their MLB same game parlay value jumps when paired with props like Freddie Freeman or Ohtani to hit safely. Arizona’s bullpen hasn’t held leads well, and with Burnes walking 22 batters already, L.A. should capitalize.

Bet on Los Angeles Dodgers (-135)

Over/Under Pick: Diamondbacks vs Dodgers Under 9 (Ev)

Corbin Burnes has a 2.56 ERA and tends to keep the ball in the yard. Dustin May’s 4.43 ERA is inflated, but his 1.28 WHIP suggests he’s not getting crushed. My MLB props today reflect this with both pitchers projected for at least 5 IP. I’m fading the bats just enough for this one to stay under.

Bet on Diamondbacks vs Dodgers Under 9 (Ev)

Get More MLB Game Picks, Expert Analysis and Best Bets

My Best Prop Bet

Player prop pick: Freddie Freeman Over 1.5 Total Bases (+120)

Freeman is hitting .371 with a .671 SLG — one of the best lines in the majors. He’s cleared 1.5 total bases in five of his last seven games and draws a righty in Burnes, who’s allowed a .267 average to lefties. He’s scorching at home and the MLB expert picks today market will be all over him. You can confidently anchor a parlay with this leg as one of my MLB best bets today.

Bet on Freddie Freeman Over 1.5 Total Bases (+120)

Since Mark Derosa is stirring up the Freddie talk again. Here is how Matt Olson has done since Freddie left.

Yep, the into 1b that has been better than Olson in MLB has been Freeman. That’s it.

Let’s stop pretending like it’s this huge drop-off. pic.twitter.com/opMmeM6fFf

— Sam Peebles (@SPeeblesSports) May 19, 2025

Game prop pick: Team to Score First – Dodgers (+107)

Dustin May’s splits are better early in games, and the Dodgers have scored first in three of their last four home contests. Arizona, meanwhile, ranks 16th in first-inning runs per game. I like the value here with May at home and Freeman/Ohtani leading off the first. MLB expert picks and parlays often overlook this market, but it’s a sharp play at plus money.

Bet on Dodgers to Score First (+107)