Dodgers vs Cubs Prediction, Picks and MLB Prop Bets, Wednesday, 4/23: Take Kyle Tucker to Knock in a Run or Two

Tuesday night’s series opener between the Dodgers and Cubs was a gem of a game, a classic that had a playoff vibe in late-April and a fantastic finish. With all eyes on a rematch Wednesday night, we’re surveying the best MLB bets for this one. Your MLB player props today should feature plenty of the big names in this matchup.

These teams should also be all over your MLB futures betting decisions, as they’ll be in the mix for everything down the road.

CUBS COMEBACK TO WALK IT OFF AGAINST THE DODGERS! pic.twitter.com/Zp1tuMh1pj

— Jomboy Media (@JomboyMedia) April 23, 2025

Dodgers vs Cubs Prediction Today, April 23, 2025

My prediction

• ATS Pick: Chicago Cubs -1.5 Runs (+176)

The Dodgers were planning a bullpen day for this one, but that was blown out of the water when Dustin May was chased early on Tuesday. They’ll likely need a Triple-A reinforcement to go up against Matthew Boyd, who has been solid out of the gate for Chicago. We like the hosts, who are 7-3-0 against the run line at home.

Bet on Cubs -1.5 (+176)

• Over/Under Pick: Dodgers at Cubs Over 9.5 Runs (-111)

After 21 runs were scored on Tuesday, and with an uncertain pitching plan from the visitors, we can expect some runs to come across in this one as well. The Cubs are 7-2-1 when going for the over at home, the best mark in the National League, and behind Kyle Tucker’s magical start, they are running away with the MLB lead in runs scored. Until you have a reason to expect an under, stay over this water line and include it in your MLB game predictions today.

Bet on Dodgers vs Cubs Over 9.5 (-111)

Dodgers vs Cubs Prop Picks and Best Bets

• Tommy Edman to Record 2+ Total Bases (+134)

Tommy Edman has 67 career home runs. Fifteen of them have come against the Cubs, including five at Wrigley Field. He only has one hit in eight career at-bats against Boyd, but it, too, was a home run. Even if Edman doesn’t go deep, he’s still a solid addition to your MLB prop picks.

Tommy Edman hits a TANK for his 8th homer of the season! pic.twitter.com/qMeUk5KEj7

— MLB (@MLB) April 22, 2025

Bet on Tommy Edman to Record 2+ Total Bases (+134)

• Kyle Tucker to Record 1+ Runs+RBIs (-139)

It’s hard not to include something on Kyle Tucker, whose hot start has talk of an extension with the Cubs among the popular items in the MLB latest news pages. This is a simple wager, but one that can be a solid base for something larger, if you choose to get wild. Tucker is tied for the MLB lead with 25 RBIs and is a great bet to add to that total.

Kyle Tucker makes it a 1-run game in the 8th inning 👀 pic.twitter.com/RZ2gKAko1G

— MLB (@MLB) April 23, 2025

Bet on Kyle Tucker to Record 1+ Runs+RBIs (-139)

• YRFI (-112)

The Cubs have scored in the first inning exactly half the time at home so far, one of the best rates in the majors. They’ll take that trend into a matchup with whatever the Dodgers throw out there in the first, which will certainly not be ace material. Boyd has been solid in the first so far this year, but he did have to work around a walk in that frame in his earlier start vs the Dodgers, and, well, it’s the Dodgers.

Bet on Score on First Inning – YES (-112)

Dodgers vs Cubs How to Watch

• Game: Los Angeles Dodgers (16-8) vs Chicago Cubs (15-10)
• Date/Time: April 23, 7:00 p.m. ET
• Location: Wrigley Field, Chicago, IL
• Dodgers vs Cubs Live Stream: MLB.tv

Check here for Dodgers vs Cubs stats.

Get More MLB Game Picks, Expert Analysis and Best Bets

• Dodgers vs Cubs Same Game Parlay Picks, Wednesday, 4/23: Back Host Cubs to Take the Win

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets