Giants vs Padres Prediction, Preview, Stream, Odds & Picks, Oct, 4.
San Diego’s Seeding
The San Diego Padres are already in the playoffs, but still, have something at stake when they host the San Francisco Giants Tuesday night.
The Padres (88-72) still have to fend off the Philadelphia Phillies to retain the No. 5 seed. If the season ended today, San Diego plays the (presumptive) fourth-seeded New York Mets. If the Padres end as the No. 6 seed, they will have to face the third-seeded St. Louis Cardinals.

The San Francisco Giants (80-80) are just trying to get to the positive side of break-even this season. The Padres won the series opener, 7-4, in a game that was scoreless going to the bottom of the eighth inning.
Let’s check the latest MLB odds, stats, injury reports, and MLB lines for Giants vs Padres. We’ve plenty of Vegas MLB odds for you to consider.
Giants’ Coin-Flip Season
Monday’s loss left the San Francisco Giants at a “perfect” 80-80 this season, in danger of a losing season just one year after leading MLB in wins. The Giants enter Tuesday with a 10-3 record in their last 13, They’ve lost their six games against the Padres however.
Lefty Carlos Rodon (14-8, 2.88 ERA) gets the Giants’ start Tuesday night. Rodon blanked the Colorado Rockies over six innings in his last start (two hits, 10 strikeouts, no walks). Rodon is ranked third in strikeouts with 237, fanning in double figures five times in his last eight outings.
Manaea’s Not the Man
If there is one thing lefthander Sean Manaea (7-9, 5.15 ERA) needs right now, it’s a turn of fortune. He’s been one of the worst starters among playoff-bound teams this season, with 7.00 ERA in his last five starts. The Padres are fighting to hold the second wild-card spot. He’s not helping.
Manaea’s poor numbers against the Giants this season include a 4.76 ERA in three starts (nine earned runs in 17 innings). Manaea is just 1-4 in his previous 10 games.
It is conceivable that the Friars lose the No. 5 seed and then be stuck with a more challenging opponent to begin the postseason.
Giants vs Padres Head-to-Head
The Padres hold a 12-5 advantage against the Giants this season.
Giants vs Padres Game Information
- Game: Giants (80-80) vs Padres (88-72)
- Location: Petco Park, San Diego, CA
- Day/Time: Tuesday, Oct. 4th, 9:40 p.m. ET
- Giants vs Padres Live stream: MLB.tv
Giants vs Padres Betting Lines
Team | Run Line | Moneyline | Total | Team Total |
San Francisco Giants
C. Rodon -L |
+1½ -175 | +129 | 7 -120o | 3½ +115o |
San Diego Padres
S. Manaea -L |
-1½ +155 | -144 | 7 Evu | 3½ -130o
3½ Evu |
The odds in this chart are based on the time of publication. They are subject to change.
Giants vs Padres Prediction
The Padres have more at stake, but lack the skill on the hill to get it done. Lefty Rodon is one of the better pitchers in the league, while Manaea isn’t producing. Expect the Giants’ lefty to be on top of his game in his last start of the season.
“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”