Guardians vs Orioles Prediction, Picks and MLB Prop Bets: Back Cleveland (+130) April 15
- Bet the Guardians’ ML (+130) to pound Orioles starter Charlie Morton.
- Take the over (Ev) as Baltimore’s pitching takes a beating vs Cleveland.
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Coming off two wins in their weekend series against Kansas City, the 8-7 Cleveland Guardians will be looking to continue their strong form even as MLB lines show them as road underdogs when they play the Baltimore Orioles in the first of three games at Camden Yards.

For the Orioles, who are 1-3 in their last four, including dropping their last home game against the Toronto Blue Jays this past Sunday, a win here could give their MLB futures bets position a boost, especially following a slow start to the season. They are currently last in the American League East standings.
With Charlie Morton taking the mound for the O’s and Logan Allen getting the nod for Cleveland, staying away from their MLB strikeout props might be key here. Instead, let’s break down a slew of picks worth targeting for this game slated to start at 7:05 p.m. ET.
Guardians vs Orioles MLB Odds Today
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Guardians vs Orioles Prediction Today April 15, 2025
My prediction
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Guardians ML (+130)
If the Guardians want to start making MLB news headlines, scoring a series win in Baltimore could be the best way to do so.
Sitting 1.5 games behind the Detroit Tigers in the AL Central, a win tonight could go a long way, which works great for a Guardians team facing Morton, who’s 0-3 record and 8.78 ERA.
I still believe this Orioles team has what it takes to light up the scene in the AL East, but with Morton pitching, there’s no rational way I’m backing them to win. So take Cleveland’s moneyline, bet the upset, and make some money thanks to Morton.
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Guardians vs Orioles Over 9 (Ev)
MLB betting trends have Orioles home games going over in four out of the last five, and in two of Morton’s three starts this season. Sticking to my gut here and banking on Morton once again dropping the ball, the over set at 9 runs (Ev) doesn’t seem too difficult to target.
Even if both teams have shown early signs of struggling to put runs up, something tells me if Cleveland’s bats heat up from early on and pound on Morton before he’s taken out, plus Baltimore tries to keep the game close, this game could go over before the 7th inning.
Bet on Guardians vs Orioles Over 9 (Ev)
Guardians vs Orioles Prop Picks and Best Bets
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Gunnar Henderson Over 0.5 Hits (-209)
For the first of my Guardians vs Orioles MLB prop picks today, I’m gunning (pun intended) on shortstop Gunnar Henderson, one of Baltimore’s best prospects, to beat his over in hits for tonight.
Why?
In his last 10 games against Cleveland, Henderson holds a .425 average with 17 hits and three home runs, per Guardians vs Orioles stats. Based on his performance on Sunday against the Blue Jays, where he had three hits, including a triple, taking him to snag at least one hit tonight feels like a sure bet.
Bet on Gunnar Henderson Over 0.5 Hits (-209)
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Guardians vs Orioles Total 1st 5 Inning Over 5 (-111)
Before you start thinking I have a thing against Morton, believe me, I don’t. But at 41 years old, and with a 0-3 record and 8.78 ERA to start the season, there’s really not much backing him to pull through tonight.
In Morton’s last outing he allowed four runs in five innings, which shows that if teams start out hot on the plate, stacking up runs on him doesn’t take that much effort. Mark my words, if Cleveland gets at least one or two runs in the first couple of innings, going over five runs in the first five will be a walk in the park for MLB predictions.
Bet on 1st 5 Inning Over 5 (-111)
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Guardians vs Orioles YRFI (-112)
I swear I don’t have anything against Morton, but facts talk and stats matter. If Cleveland gets on base with a couple of outs to spare to start the game, there will be at least one run in the first.
Bet on Guardians vs Orioles YRFI (-112)
Guardians vs Orioles Game Information
- Game: Guardians (8-7) vs Orioles (6-9)
- Date/Time: Tuesday, April 15, 7:05 p.m. ET
- Location: Camden Yards, Baltimore, Maryland
- Padres vs Cubs Live Stream: MLB.TV
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