Guardians vs Tigers Prediction, MLB Prop Bets and Parlay Picks for Saturday, 5/24

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- Add Detroit -1.5 to your Guardians vs Tigers picks today.
- Bet on Cleveland’s Luis Ortiz over 4.5 strikeouts
Guardians vs Tigers Prediction and Best Bets Today, 5/24
My prediction
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Run Line Pick: Guardians +1.5 (-170)
Game 3 of the Guardians vs Tigers series is on our doorstep, and it’s been all Cleveland thus far, as it has taken the first two games. The Tigers have had a solid season, but against the Guardians? They’ve looked like a high school team. That’s why I’m backing Cleveland on the MLB odds today to make it three straight. Look, I expect Detroit to show some life at the plate, but it won’t be enough to counter Cleveland’s momentum. Take the runs.
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Guardians vs Tigers Under 8.5 Runs (-125)
Cleveland has been better at the plate in this series, no doubt. And while Detroit’s struggled in this series, it is still fourth in runs and can break out if given the chance. Still, I like the under for my MLB parlay bets today. Hear me out: both teams should get on the board, but with Cleveland’s Luis Ortiz and Detroit’s Casey Mize on the mound, I’m trusting the arms to keep this in check. Be smart – ride the under.
Bet On Guardians vs Tigers Under 8.5 (-125)
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My Best Prop Bets
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Guardians P Luis Ortiz Over 4.5 Strikeouts (-143)
Even though I am calling for the Tigers’ bats to wake up a bit, I’m still including Guardians righty Ortiz to rack up over 4.5 strikeouts for my MLB prop bets today. Ortiz might be 2-5 on the season, but he’s been collecting strikeouts like it’s a video game, recording 16 over his last two outings. That said, with momentum on his side and Detroit’s bats struggling, Ortiz should keep the strikeouts coming.
Bet On Luis Ortiz Over 4.5 Strikeouts (-143)
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Guardians vs Tigers Under 16.5 Total Hits (-130)
The first two games between these teams show that hitting hasn’t been great in terms of hit count. While you might think this game would suddenly turn into a hit fest, my MLB predictions say otherwise. Listen, both games struggled to crack 14 total hits, let alone 17.
Factor in Saturday night’s mound matchup, and I’m not buying a sudden offensive explosion. Play it safe and take the under for your MLB parlay picks today
Bet On Guardians vs Tigers Under 16.5 Total Hits (-130)
Guardians vs Tigers Same Game Parlay Picks Today, 5/24
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Guardians vs Tigers How To Watch
- Game: Cleveland Guardians (28-22) vs Detroit Tigers (33-19)
- Date/Time: Saturday, May 24, 7:15 p.m. ET
- Location: Comerica Park, Detroit, MI
- Guardians vs Tigers Live Stream: MLB.tv
Get the latest Guardians vs Tigers betting trends here.
Dodgers vs Mets MLB FAQs
Who leads the Tigers in home runs this season?
Detroit’s Spencer Torkelson hit his team-leading 13th home run on Friday night.
What is Cleveland’s record on the road in 2025?
The Guardians have won the first two games in this series to even their record away from home this season at 14-14.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets