Guardians vs Twins Prediction, MLB Prop Bets and Parlay Picks for Monday, 5/19

Mark Rich

· May 19 - 4 minutes read

Guardians

Cleveland Guardians

Twins

Minnesota Twins

+120

Money Line Game

-132

+1½ -185

Run Line Game

-1½ +160

Over 7½ -105

Total Game

Under 7½ -115

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Guardians vs Twins Prediction, MLB Prop Bets and Parlay Picks for Monday, 5/19 — Minnesota Twins designated hitter Ryan Jeffers (27) | Benny Sieu-Imagn Images

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We’re taking the Twins (-135) to start their series with the Guardians with a win.
Bet on Minnesota’s Ryan Jeffers to stay hot with 1+ hits.

Guardians vs Twins Prediction and Best Bets Today, May 19

My prediction

Moneyline Pick: Twins -133

Minnesota is coming off its first loss in two weeks, and it certainly wants to rebound in the opener of this key series with Cleveland. Having Bailey Ober (4-1, 3.72 ERA, 40 Ks) on the mound will certainly help against a struggling Guardians squad that comes into this one on a four-game losing skid. Take Minnesota to have the advantage at home and pick up the win when making your best MLB parlay picks today.

Bet on Twins ML -133

Guardian vs Twins Under 7.5 Runs

The season series between these clubs has been dominated by Cleveland so far, as it took three of four in the first series in late April. Only one of those games finished above seven runs, however, so don’t expect a ton of offense on Monday night. Another of our top MLB expert picks is taking the under.

Bet on Guardians vs Twins Under 7.5 Runs (-115)

My Best Prop Bets

Twins C Ryan Jeffers 1+ Hits

Ryan Jeffers doesn’t have standout numbers for the season at the plate, but he’s coming off a very good weekend against the Milwaukee Brewers. Jeffers went 6-for-14 in the three-game series against the Brewers, including coming up a triple short of the cycle in Saturday’s win.

Ryan Jeffers SMOKED this ball 😲#MNTwins
pic.twitter.com/08Jg99gFvE

— Twins Talk (@LetsTalk_Twins) May 17, 2025

Jeffers is batting .268 on the campaign, but he has at least one hit in eight of 13 games in May. One of the better MLB player prop bets is Jeffers making that nine of 14, as he’ll record at least one hit in the series opener.

Bet on Ryan Jeffers 1+ Hits (-209)

Team With The Highest Scoring Inning: Twins

Outside of Sunday’s loss to Milwaukee, Minnesota has been hitting the ball well and has been helped by a shutout streak of 34 innings that was snapped on Sunday. The Twins have been tough at home this season, going 15-6, and they’ll be looking to bounce back after their win and shutout streaks were ended. We see them coming out on top in this one, so we’re adding the Twins having the highest scoring inning in the opener to our MLB parlay picks for this contest.

Bet on Team With The Highest Scoring Inning: Twins (+125)